Breast cancer is the second leading cause of cancer deaths among women. The
development of breast cancer is a multi-step process involving multiple cell types, and its …

BACKGROUND Meiosis is an essential stage in the life cycle of sexually reproducing
species, underlying formation of haploid gametes and serving as the basis of genetic …

To fully exploit the potential of single-cell functional genomics in the study of development
and disease, robust methods are needed to simplify the analysis of data across samples …

The inheritance of monoallelic germline mutations affecting BRCA1 or BRCA2 predisposes
with a high penetrance to several forms of epithelial malignancy. The large, nuclear …

Fanconi anemia (FA) is a life-threatening syndrome characterized by bone marrow failure
and cancer predispositions. The past two decades have seen an explosion of data in the FA …

DNA Holliday junction (HJ) is a four-way stranded DNA intermediate that formed in
replication fork regression, homology-dependent repair and mitosis, performing a significant …

Breast cancer risks conferred by many germline missense variants in the BRCA1 and
BRCA2 genes, often referred to as variants of uncertain significance (VUS), have not been …

Homologous recombination (HR) repairs DNA double-strand breaks (DSBs) to maintain
genomic integrity. Recombinase recruited to the DSBs by the mediator protein BRCA2 …

BRCA2 is essential for DNA repair by homologous recombination in mitosis and meiosis. It
interacts with recombinases RAD51 and DMC1 to facilitate the formation of nucleoprotein …

Breast cancer susceptibility gene II (BRCA2) is central in homologous recombination (HR).
In meiosis, BRCA2 binds to MEILB2 to localize to DNA double-strand breaks (DSBs). Here …