Collective cancer invasion with leader–follower organization is increasingly recognized as a
predominant mechanism in the metastatic cascade. Leader cells support cancer invasion by …

E-cadherin is a key component of the adherens junctions that are integral in cell adhesion
and maintaining epithelial phenotype of cells. Homophilic E-cadherin binding between cells …

Collective cell migration is a key driver of embryonic development, wound healing, and
some types of cancer invasion. Here, we provide a physical perspective of the mechanisms …

Collective cell migration has a key role during morphogenesis and during wound healing
and tissue renewal in the adult, and it is involved in cancer spreading. In addition to …

Recent genomic studies challenge the conventional model that each metastasis must arise
from a single tumor cell and instead reveal that metastases can be composed of multiple …

Collective cell migration critically depends on cell–cell interactions coupled to a dynamic
actin cytoskeleton. Important cell–cell adhesion receptor systems implicated in controlling …

Cancer invasion is a cell-and tissue-driven process for which the physical, cellular, and
molecular determinants adapt and react throughout the progression of the disease. Cancer …

Most invasive solid tumours display predominantly collective invasion, in which groups of
cells invade the peritumoral stroma while maintaining cell–cell contacts. As the concepts …

Growing evidence for intratumour heterogeneity informs us that single-site biopsies fall short
of revealing the complete genomic landscape of a tumour. With an expanding repertoire of …

Metastasis is the leading cause of cancer mortality. The metastatic cascade represents a
multi-step process which includes local tumor cell invasion, entry into the vasculature …