A central goal of genetics is to understand the links between genetic variation and disease.
Intuitively, one might expect disease-causing variants to cluster into key pathways that drive …

The contribution of host genetic and nongenetic factors to immunological differences in
humans remains largely undefined. Here, we generated bacterial-, fungal-, and viral …

The immune system plays a major role in human health and disease, and understanding
genetic causes of interindividual variability of immune responses is vital. Here, we isolate …

Anthracycline-induced cardiotoxicity (ACT) is a key limiting factor in setting optimal
chemotherapy regimes, with almost half of patients expected to develop congestive heart …

Induced pluripotent stem cells (iPSCs) are an essential tool for studying cellular
differentiation and cell types that are otherwise difficult to access. We investigated the use of …

A growing knowledge base of genetic and environmental information has greatly enabled
the study of disease risk factors. However, the computational complexity and statistical …

Puberty is an important developmental period marked by hormonal, metabolic and immune
changes. Puberty also marks a shift in sex differences in susceptibility to asthma. Yet, little is …

Genetic and environmental factors both contribute to islet dysfunction and failure, resulting in
type 2 diabetes (T2D). The islet epigenome integrates these cues and can be remodeled by …

Gene regulation is a complex process, which dictates how the body reacts to different
situations through gene expression. Enhancers are sequences of a few hundred base pairs …