Natriuretic peptides, which are activated in heart failure, play an important cardioprotective
role. The most notable of the cardioprotective natriuretic peptides are atrial natriuretic …

The principal cell of the kidney collecting duct is one of the most highly regulated epithelial
cell types in vertebrates. The effects of hormonal, autocrine, and paracrine factors to regulate …

Diabetic kidney disease remains the most common cause of end-stage kidney disease in
the world. Despite reductions in incidence rates of myocardial infarction and stroke in people …

Abstract Background Aquaporins (AQPs) are a family of proteins that can act as water
channels. Regulation of AQPs is critical to osmoregulation and the maintenance of body …

Aquaporins (AQPs) are a family of membrane water channels that basically function as
regulators of intracellular and intercellular water flow. To date, thirteen AQPs, which are …

The balance between vasoconstrictor/sodium-retaining and vasodilator/natriuretic systems
is essential for maintaining body fluid and electrolyte homeostasis. Natriuretic peptides, such …

Under physiological conditions, excessive loss of water through the urine is prevented by
the release of the antidiuretic hormone arginine-vasopressin (AVP) from the posterior …

The cellular functions of many eukaryotic membrane proteins, including the vasopressin-
regulated water channel aquaporin-2 (AQP2), are regulated by posttranslational …

Regulation of our water homeostasis is fine-tuned by dynamic translocation of Aquaporin-2
(AQP2)-bearing vesicles to and from the plasma membrane of renal principal cells. Whereas …

Studies of experimental diabetes mellitus (DM) suggest that increased nitric oxide (NO)
bioactivity contributes to renal hyperfiltration. However, the role of NO in mediating …