The complex interplay of iron metabolism, reactive oxygen species, and reactive nitrogen species: insights into the potential of various iron therapies to induce …

TS Koskenkorva-Frank, G Weiss, WH Koppenol… - Free Radical Biology …, 2013 - Elsevier
Production of minute concentrations of superoxide (O 2 radical dot−) and nitrogen monoxide
(nitric oxide, NO radical dot) plays important roles in several aspects of cellular signaling …

eNOS at a glance

WC Sessa - Journal of cell science, 2004 - journals.biologists.com
2428 caveolae (García-Cardeña et al., 1996; Liu et al., 1995; Liu et al., 1997; Liu and Sessa,
1994). Similar to nNOS and iNOS, eNOS contains a C-terminal reductase domain, which …

Nitric oxide function in the skin

MM Cals-Grierson, AD Ormerod - Nitric oxide, 2004 - Elsevier
Endogenously produced nitric oxide (NO) has a remarkably diverse range of biological
functions, including a role in neurotransmission, smooth muscle relaxation, and the …

The chemistry of nitroxyl (HNO) and implications in biology

KM Miranda - Coordination Chemistry Reviews, 2005 - Elsevier
Over the past century, HNO research has evolved from fundamental physical examinations
to elucidation of interactions in atmospheric, industrial and bacterial processes. Most …

Nitroxyl (HNO): the Cinderella of the nitric oxide story

JC Irvine, RH Ritchie, JL Favaloro, KL Andrews… - Trends in …, 2008 - cell.com
Until recently, most of the biological effects of nitric oxide (NO) have been attributed to its
uncharged state (NO), yet NO can also exist in the reduced state as nitroxyl (HNO or NO−) …

A biochemical rationale for the discrete behavior of nitroxyl and nitric oxide in the cardiovascular system

KM Miranda, N Paolocci, T Katori… - Proceedings of the …, 2003 - National Acad Sciences
The redox siblings nitroxyl (HNO) and nitric oxide (NO) have often been assumed to
undergo casual redox reactions in biological systems. However, several recent studies have …

[HTML][HTML] Cardioprotection: a radical view: free radicals in pre and postconditioning

C Penna, D Mancardi, R Rastaldo, P Pagliaro - Biochimica et Biophysica …, 2009 - Elsevier
A series of brief (a few minutes) ischemia/reperfusion cycles (ischemic preconditioning, IP)
limits myocardial injury produced by a subsequent prolonged period of coronary artery …

Reaction Discovery Using Spectroscopic Insights from an Enzymatic C–H Amination Intermediate

A Das, S Gao, RG Lal, MH Hicks… - Journal of the …, 2024 - ACS Publications
Engineered hemoproteins can selectively incorporate nitrogen from nitrene precursors like
hydroxylamine, O-substituted hydroxylamines, and organic azides into organic molecules …

Nitroxyl affords thiol-sensitive myocardial protective effects akin to early preconditioning

P Pagliaro, D Mancardi, R Rastaldo, C Penna… - Free Radical Biology …, 2003 - Elsevier
Nitric oxide (NO) donors mimic the early phase of ischemic preconditioning (IPC). The
effects of nitroxyl (HNO/NO−), the one-electron reduction product of NO, on …

The chemical biology of the persulfide (RSSH)/perthiyl (RSS·) redox couple and possible role in biological redox signaling

CL Bianco, TA Chavez, V Sosa, SS Simran… - Free Radical Biology …, 2016 - Elsevier
The recent finding that hydropersulfides (RSSH) are biologically prevalent in mammalian
systems has prompted further investigation of their chemical properties in order to provide a …