The ErbB receptor family, also known as the EGF receptor family or type I receptor family,
includes the epidermal growth factor (EGF) receptor (EGFR) or ErbB1/Her1, ErbB2/Her2 …

The human epidermal growth factor receptor (EGFR) family consists of four members that
belong to the ErbB lineage of proteins (ErbB1–4). These receptors consist of a glycosylated …

Metabolic production of acetyl coenzyme A (acetyl-CoA) is linked to histone acetylation and
gene regulation, but the precise mechanisms of this process are largely unknown. Here we …

Neuregulins (NRGs) comprise a large family of growth factors that stimulate ERBB receptor
tyrosine kinases. NRGs and their receptors, ERBBs, have been identified as susceptibility …

The cognitive abilities of humans are distinctive among primates, but their molecular and
cellular substrates are poorly understood. We used comparative single-nucleus …

Astrocytes are no longer seen as a homogenous population of cells. In fact, recent studies
indicate that astrocytes are morphologically and functionally diverse and play critical roles in …

Oligodendrocytes and astrocytes are macroglial cells of the vertebrate central nervous
system. These cells have diverse roles in the maintenance of neurological function. In the …

An important pathological feature of Alzheimer's disease (AD) is the presence of
extracellular senile plaques in the brain. Senile plaques are composed of aggregations of …

Presenilins were first discovered as sites of missense mutations responsible for early-onset
Alzheimer disease (AD). The encoded multipass membrane proteins were subsequently …

Skeletal muscle stem cells have a central role in muscle growth and regeneration. They
reside as quiescent cells in resting muscle and in response to damage they transiently …