Allogeneic hematopoietic cell transplantation involves consideration of both donor and
recipient characteristics to guide the selection of a suitable graft. Sufficient high-resolution …

Natural killer (NK) cells play an important role in surveillance and elimination of malignant
cells. Their spontaneous cytotoxicity was first demonstrated in vitro against leukemia cell …

Allogeneic stem cell transplantation is an effective treatment for high-risk myeloid
malignancies, but relapse remains the major post-transplantation cause of treatment failure …

Natural killer (NK) cells play a significant role in immune tolerance and immune surveillance.
Killer immunoglobin-like receptors (KIRs), which recognize human leukocyte antigen (HLA) …

Natural killer (NK) cell recognition and killing of target cells are enhanced when inhibitory
killer immunoglobulin-like receptors (KIR) are unable to engage their cognate HLA class I …

In acute myeloid leukemia (AML), donor natural killer cell killer immunoglobulin–like
receptors (KIR) and recipient HLA interactions may contribute to the graft-versus-leukemia …

Multiple models of donor killer immunoglobulin receptor (KIR) alloreactivity or KIR genotype
have been reported to be protective against leukemia relapse after allogeneic …

Besides donor T cells, natural killer (NK) cells are considered to have a major role in
preventing relapse after allogeneic hematopoietic stem cell transplantation (HSCT). After T …

Results from registry studies suggest that harnessing Natural Killer (NK) cell reactivity
mediated through Killer cell Immunoglobulin-like Receptors (KIR) could reduce the risk of …

Natural killer cells were first described over 40 years ago, but the last 15 years has shown
tremendous progress in our understanding of their biology and our ability to manipulate …