Molecular diversity sculpted by fungal PKS–NRPS hybrids
D Boettger, C Hertweck - ChemBioChem, 2013 - Wiley Online Library
Fungal polyketide synthase–nonribosomal peptide synthetase (PKS–NRPS) hybrids
manufacture a wide range of structurally diverse secondary metabolites that play an eminent …
manufacture a wide range of structurally diverse secondary metabolites that play an eminent …
Biosynthesis of natural products by microbial iterative hybrid PKS–NRPS
KM Fisch - RSC advances, 2013 - pubs.rsc.org
Biosynthesis of natural products by microbial iterative hybrid PKS–NRPS - RSC Advances (RSC
Publishing) DOI:10.1039/C3RA42661K Royal Society of Chemistry View PDF VersionPrevious …
Publishing) DOI:10.1039/C3RA42661K Royal Society of Chemistry View PDF VersionPrevious …
Genomics-driven discovery of the pneumocandin biosynthetic gene cluster in the fungus Glarea lozoyensis
Background The antifungal therapy caspofungin is a semi-synthetic derivative of
pneumocandin B 0, a lipohexapeptide produced by the fungus Glarea lozoyensis, and was …
pneumocandin B 0, a lipohexapeptide produced by the fungus Glarea lozoyensis, and was …
Cladosins A–E, Hybrid Polyketides from a Deep-Sea-Derived Fungus, Cladosporium sphaerospermum
Five new fungal hybrid polyketides, cladosins A–D (1–4), that contain a novel linear 6 (3)-
enamino-8, 10-dihydroxy-tetraketide (1 and 2) or 6-enamino-7 (8)-en-10-ol (3 and 4) moiety …
enamino-8, 10-dihydroxy-tetraketide (1 and 2) or 6-enamino-7 (8)-en-10-ol (3 and 4) moiety …
Predicting the chemical space of fungal polyketides by phylogeny-based bioinformatics analysis of polyketide synthase-nonribosomal peptide synthetase and its …
A Minami, T Ugai, T Ozaki, H Oikawa - Scientific reports, 2020 - nature.com
Fungal polyketide synthase (PKS)–nonribosomal peptide synthetase (NRPS) hybrids are
key enzymes for synthesizing structurally diverse hybrid natural products (NPs) with …
key enzymes for synthesizing structurally diverse hybrid natural products (NPs) with …
Fungal natural products galaxy: Biochemistry and molecular genetics toward blockbuster drugs discovery
K Bhattarai, ME Kabir, R Bastola, B Baral - Advances in genetics, 2021 - Elsevier
Secondary metabolites synthesized by fungi have become a precious source of inspiration
for the design of novel drugs. Indeed, fungi are prolific producers of fascinating, diverse …
for the design of novel drugs. Indeed, fungi are prolific producers of fascinating, diverse …
Xyolide, a bioactive nonenolide from an Amazonian endophytic fungus, Xylaria feejeensis
Endophytes isolated from tropical plants represent a largely untapped reservoir of bioactive
secondary metabolites. We screened a library of fungal endophyte extracts for inhibition of …
secondary metabolites. We screened a library of fungal endophyte extracts for inhibition of …
Evolutionary imprint of catalytic domains in fungal PKS–NRPS hybrids
D Boettger, H Bergmann, B Kuehn, E Shelest… - …, 2012 - Wiley Online Library
Fungal hybrid enzymes consisting of a polyketide synthase (PKS) and a nonribosomal
peptide synthetase (NRPS) module are involved in the biosynthesis of a vast array of …
peptide synthetase (NRPS) module are involved in the biosynthesis of a vast array of …
[HTML][HTML] Synthetic microbes and biocatalyst designs in Thailand
D Trisrivirat, R Tinikul, P Chaiyen - Biotechnology Notes, 2023 - Elsevier
Furthering the development of the field of synthetic biology in Thailand is included in the
Thai government's Bio-Circular-Green (BCG) economic policy. The BCG model has …
Thai government's Bio-Circular-Green (BCG) economic policy. The BCG model has …
Biosynthesis of Calipyridone A Represents a Fungal 2-Pyridone Formation without Ring Expansion in Aspergillus californicus
A chemical investigation of the filamentous fungus Aspergillus californicus led to the
isolation of a polyketide–nonribosomal peptide hybrid, calipyridone A (1). A putative …
isolation of a polyketide–nonribosomal peptide hybrid, calipyridone A (1). A putative …