▪ Abstract Neurotrophins regulate development, maintenance, and function of vertebrate
nervous systems. Neurotrophins activate two different classes of receptors, the Trk family of …

The formation of functional neural circuits in the vertebrate central nervous system (CNS)
requires that appropriate numbers of the correct types of neuronal and glial cells are …

Different types of spiral ganglion neurons (SGNs) are essential for auditory perception by
transmitting complex auditory information from hair cells (HCs) to the brain. Here, we use …

▪ Abstract The neurons of the cochlear ganglion transmit acoustic information between the
inner ear and the brain. These placodally derived neurons must produce a topographically …

We investigated whether co‐expression of Neurog1 and Atoh1 in common neurosensory
precursors could explain the loss of hair cells in Neurog1 null mice. Analysis of terminal …

The homeobox Six genes, homologues to Drosophila sine oculis (so) gene, are expressed
in multiple organs during mammalian development. However, their roles during auditory …

Production and secretion of insulin from the β-cells of the pancreas is very crucial in
maintaining normoglycaemia. This is achieved by tight regulation of insulin synthesis and …

Sensory fibers of the peripheral nervous system carry sensation from specific sense
structures or use different tissues and organs as receptive fields, and convey this information …

Previous work suggested qualitatively different effects of neurotrophin 3 (NT-3) in cochlear
innervation patterning in different null mutants. We now show that all NT-3 null mutants have …

The afferent innervation of the cochlea is comprised of spiral ganglion neurons (SGNs),
which are characterized into four subtypes (Type 1A, B, and C and Type 2). However, little is …