Association between insulin resistance and the development of cardiovascular disease

V Ormazabal, S Nair, O Elfeky, C Aguayo… - Cardiovascular …, 2018 - Springer
For many years, cardiovascular disease (CVD) has been the leading cause of death around
the world. Often associated with CVD are comorbidities such as obesity, abnormal lipid …

Obesity, kidney dysfunction and hypertension: mechanistic links

JE Hall, JM do Carmo, AA da Silva, Z Wang… - Nature reviews …, 2019 - nature.com
Excessive adiposity raises blood pressure and accounts for 65–75% of primary
hypertension, which is a major driver of cardiovascular and kidney diseases. In obesity …

Overview of epidemiology and contribution of obesity and body fat distribution to cardiovascular disease: an update

ME Piché, P Poirier, I Lemieux, JP Després - Progress in cardiovascular …, 2018 - Elsevier
Obesity is recognized as a heterogeneous condition in which individuals with similar body
mass index may have distinct metabolic and cardiovascular risk profiles. Susceptibility to …

Impaired adipogenesis and dysfunctional adipose tissue in human hypertrophic obesity

A Hammarstedt, S Gogg, S Hedjazifar… - Physiological …, 2018 - journals.physiology.org
The subcutaneous adipose tissue (SAT) is the largest and best storage site for excess lipids.
However, it has a limited ability to expand by recruiting and/or differentiating available …

Molecular mechanisms of coronary microvascular endothelial dysfunction in diabetes mellitus: focus on mitochondrial quality surveillance

D Sun, J Wang, S Toan, D Muid, R Li, X Chang, H Zhou - Angiogenesis, 2022 - Springer
Coronary microvascular endothelial dysfunction is both a culprit and a victim of diabetes,
and can accelerate diabetes-related microvascular and macrovascular complications by …

[HTML][HTML] Pathophysiology of obesity and its associated diseases

X Jin, T Qiu, L Li, R Yu, X Chen, C Li, CG Proud… - … Pharmaceutica Sinica B, 2023 - Elsevier
The occurrence of obesity has increased across the whole world. Many epidemiological
studies have indicated that obesity strongly contributes to the development of cancer …

[HTML][HTML] α-Tocopherol preserves cardiac function by reducing oxidative stress and inflammation in ischemia/reperfusion injury

M Wallert, M Ziegler, X Wang, A Maluenda, X Xu… - Redox biology, 2019 - Elsevier
Objective Myocardial infarction (MI) is a leading cause of mortality and morbidity worldwide
and new treatment strategies are highly sought-after. Paradoxically, reperfusion of the …

The role of CD36 in cardiovascular disease

H Shu, Y Peng, W Hang, J Nie, N Zhou… - Cardiovascular …, 2022 - academic.oup.com
CD36, also known as the scavenger receptor B2, is a multifunctional receptor widely
expressed in various organs. CD36 plays a crucial role in the uptake of long-chain fatty …

Metabolic alterations in sepsis

W Wasyluk, A Zwolak - Journal of clinical medicine, 2021 - mdpi.com
Sepsis is defined as “life-threatening organ dysfunction caused by a dysregulated host
response to infection”. Contrary to the older definitions, the current one not only focuses on …

Inflammaging as a common ground for the development and maintenance of sarcopenia, obesity, cardiomyopathy and dysbiosis

G Livshits, A Kalinkovich - Ageing research reviews, 2019 - Elsevier
Sarcopenia, obesity and their coexistence, obese sarcopenia (OBSP) as well as
atherosclerosis-related cardio-vascular diseases (ACVDs), including chronic heart failure …