The human immune system comprises cellular and molecular components designed to
coordinately prevent infection while avoiding potentially harmful inflammation and …

The human neonate and infant are unduly susceptible to infection with a wide variety of
microbes. This susceptibility is thought to reflect differences from adults in innate and …

Newborns and young infants suffer increased infectious morbidity and mortality as
compared to older children and adults. Morbidity and mortality due to infection are highest …

Newborn infants, including those born at term without congenital disorders, are at high risk
of severe disease from respiratory syncytial virus (RSV) infection. Indeed, our current local …

Abstract Purpose of Review The purpose of this review is to provide an overview of
diagnostic testing in primary immunodeficiency and immune dysregulatory disorders …

Respiratory diseases are the most frequent chronic illnesses in babies and children.
Although a vigorous innate immune system is critical for maintaining lung health, a balanced …

Tuberculosis (TB) is still a global health concern, especially in resource-poor countries such
as The Gambia. Defining protective immunity to TB is challenging: its pathogenesis is …

Background: Antimicrobial responses have been shown to be profoundly attenuated in very
preterm neonates when examined on cord blood. However, we lack data on these …

Background. Infants born prematurely are highly vulnerable to infections and also exhibit a
high susceptibility to organ damage due to inflammation. Methods. To investigate …

Monitoring functional competence of immune cell populations in clinical routine represents a
major challenge. We developed a whole-blood assay to monitor functional competence of …