An inflammatory microenvironment, either conferred by an underlying chronic overt or
smoldering inflammatory condition constitutes a prerequisite and fuel to essentially all …

Reprogrammed metabolism is a hallmark of colorectal cancer (CRC). CRC cells are geared
toward rapid proliferation, requiring nutrients and the removal of cellular waste in nutrient …

Nutriments have been deemed to impact all physiopathologic processes. Recent evidences
in molecular medicine and clinical trials have demonstrated that adequate nutrition …

The gut microbiota modulates immune processes both locally and systemically. This
includes whether and how the immune system reacts to emerging tumours, whether …

Cancer cells frequently alter their lipids to grow and adapt to their environment,–. Despite
the critical functions of lipid metabolism in membrane physiology, signalling and energy …

Colorectal cancer (CRC) is the most common cancer of the digestive system with high
mortality and morbidity rates. Gut microbiota is found in the intestines, especially the …

Important colorectal cancer (CRC) studies in 2021, including a new standard of care for first-
line treatment of MSI-H–dMMR metastatic CRC, single-cell and spatial analysis of primary …

A hallmark of cancer is the avoidance of immune destruction. This process has been
primarily investigated in locally advanced or metastatic cancer,–; however, much less is …

Intestinal epithelial cells have the capacity to upregulate MHCII molecules in response to
certain epithelial-adhesive microbes, such as segmented filamentous bacteria (SFB) …

Tumours exhibit notable metabolic alterations compared with their corresponding normal
tissue counterparts. These metabolic alterations can support anabolic growth, enable …