Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's …
DB Kell - Archives of toxicology, 2010 - Springer
Exposure to a variety of toxins and/or infectious agents leads to disease, degeneration and
death, often characterised by circumstances in which cells or tissues do not merely die and …
death, often characterised by circumstances in which cells or tissues do not merely die and …
Reconciled rat and human metabolic networks for comparative toxicogenomics and biomarker predictions
The laboratory rat has been used as a surrogate to study human biology for more than a
century. Here we present the first genome-scale network reconstruction of Rattus norvegicus …
century. Here we present the first genome-scale network reconstruction of Rattus norvegicus …
Iron deficiency in pulmonary arterial hypertension: a deep dive into the mechanisms
M Quatredeniers, P Mendes-Ferreira, D Santos-Ribeiro… - Cells, 2021 - mdpi.com
Pulmonary arterial hypertension (PAH) is a severe cardiovascular disease that is caused by
the progressive occlusion of the distal pulmonary arteries, eventually leading to right heart …
the progressive occlusion of the distal pulmonary arteries, eventually leading to right heart …
Gut microbiota profile identifies transition from compensated cardiac hypertrophy to heart failure in hypertensive rats
E Gutiérrez-Calabrés, A Ortega-Hernández… - …, 2020 - Am Heart Assoc
Microcirculatory alterations displayed by patients with heart failure (HF) induce structural
and functional intestinal changes that may affect normal gut microbial community. At the …
and functional intestinal changes that may affect normal gut microbial community. At the …
Meta-analysis of some physiologic, metabolic and oxidative responses of sheep exposed to environmental heat stress
A meta-analysis was performed from 66 references retained from a total of 147 ones. The
aim was to study the relationship between the THI and some physiologic, metabolic and …
aim was to study the relationship between the THI and some physiologic, metabolic and …
Adrenergic and glucocorticoid receptor antagonists reduce ozone-induced lung injury and inflammation
AR Henriquez, SJ Snow, MC Schladweiler… - Toxicology and applied …, 2018 - Elsevier
Recent studies showed that the circulating stress hormones, epinephrine and
corticosterone/cortisol, are involved in mediating ozone-induced pulmonary effects through …
corticosterone/cortisol, are involved in mediating ozone-induced pulmonary effects through …
Model combustion-generated particulate matter containing persistent free radicals redox cycle to produce reactive oxygen species
MA Kelley, VY Hebert, TM Thibeaux… - Chemical research in …, 2013 - ACS Publications
Particulate matter (PM) is emitted during thermal decomposition of waste. During this
process, aromatic compounds chemisorb to the surface of metal-oxide-containing PM …
process, aromatic compounds chemisorb to the surface of metal-oxide-containing PM …
The dynamicity of acute ozone-induced systemic leukocyte trafficking and adrenal-derived stress hormones
AR Henriquez, W Williams, SJ Snow, MC Schladweiler… - Toxicology, 2021 - Elsevier
Ozone exposure induces neuroendocrine stress response, which causes lymphopenia. It
was hypothesized that ozone-induced increases in stress hormones will temporally follow …
was hypothesized that ozone-induced increases in stress hormones will temporally follow …
Zinc prevents the development of diabetic cardiomyopathy in db/db mice
S Wang, B Wang, Y Wang, Q Tong, Q Liu… - International Journal of …, 2017 - mdpi.com
Diabetic cardiomyopathy (DCM) is highly prevalent in type 2 diabetes (T2DM) patients. Zinc
is an important essential trace metal, whose deficiency is associated with various chronic …
is an important essential trace metal, whose deficiency is associated with various chronic …
Beta-2 adrenergic and glucocorticoid receptor agonists modulate ozone-induced pulmonary protein leakage and inflammation in healthy and adrenalectomized rats
AR Henriquez, SJ Snow, MC Schladweiler… - Toxicological …, 2018 - academic.oup.com
We have shown that acute ozone inhalation activates sympathetic-adrenal-medullary and
hypothalamus-pituitary-adrenal stress axes, and adrenalectomy (AD) inhibits ozone-induced …
hypothalamus-pituitary-adrenal stress axes, and adrenalectomy (AD) inhibits ozone-induced …