Metallodrugs are unique: Opportunities and challenges of discovery and development

EJ Anthony, EM Bolitho, HE Bridgewater… - Chemical …, 2020 - pubs.rsc.org
Metals play vital roles in nutrients and medicines and provide chemical functionalities that
are not accessible to purely organic compounds. At least 10 metals are essential for human …

Conjugated photosensitizers for imaging and PDT in cancer research

JCS Simões, S Sarpaki… - Journal of medicinal …, 2020 - ACS Publications
Early cancer detection and perfect understanding of the disease are imperative toward
efficient treatments. It is straightforward that, for choosing a specific cancer treatment …

Coordinating radiometals of copper, gallium, indium, yttrium, and zirconium for PET and SPECT imaging of disease

TJ Wadas, EH Wong, GR Weisman… - Chemical …, 2010 - ACS Publications
Molecular imaging is the visualization, characterization, and measurement of biological
processes at the molecular and cellular levels in humans and other living systems …

Radioactive 198Au-Doped Nanostructures with Different Shapes for In Vivo Analyses of Their Biodistribution, Tumor Uptake, and Intratumoral Distribution

KCL Black, Y Wang, HP Luehmann, X Cai, W Xing… - ACS …, 2014 - ACS Publications
With Au nanocages as an example, we recently demonstrated that radioactive 198Au could
be incorporated into the crystal lattice of Au nanostructures for simple and reliable …

Applications of radiocomplexes with thiosemicarbazones and bis (thiosemicarbazones) in diagnostic and therapeutic nuclear medicine

GL Parrilha, RG dos Santos, H Beraldo - Coordination Chemistry Reviews, 2022 - Elsevier
Metallic radionuclides possess a variety of half-lives, emission types, energies, and
branching ratios, making it possible to apply them as diagnostic and/or therapeutic agents …

Copper-64 radiopharmaceuticals for PET imaging of cancer: advances in preclinical and clinical research

CJ Anderson, R Ferdani - Cancer Biotherapy and …, 2009 - liebertpub.com
Summation Copper-64 (T1/2= 12.7 hours; β+, 0.653 MeV [17.8%]; β−, 0.579 MeV [38.4%])
has decay characteristics that allow for positron emission tomography (PET) imaging and …

Hypoxia: importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy

JL Tatum - International journal of radiation biology, 2006 - Taylor & Francis
Purpose: The Cancer Imaging Program of the National Cancer Institute convened a
workshop to assess the current status of hypoxia imaging, to assess what is known about the …

Molecular imaging of hypoxia

KA Krohn, JM Link, RP Mason - Journal of Nuclear Medicine, 2008 - Soc Nuclear Med
Hypoxia, a condition of insufficient O 2 to support metabolism, occurs when the vascular
supply is interrupted, as in stroke or myocardial infarction, or when a tumor outgrows its …

[HTML][HTML] PET radiopharmaceuticals for imaging of tumor hypoxia: a review of the evidence

E Lopci, I Grassi, A Chiti, C Nanni… - American journal of …, 2014 - ncbi.nlm.nih.gov
Hypoxia is a pathological condition arising in living tissues when oxygen supply does not
adequately cover the cellular metabolic demand. Detection of this phenomenon in tumors is …

Copper complexes as therapeutic agents

C Duncan, AR White - Metallomics, 2012 - academic.oup.com
The importance of transition metals in biological processes has been well established.
Copper (Cu) is a transition metal that can exist in oxidised and reduced states. This allows it …