Getting out of mitosis: spatial and temporal control of mitotic exit and cytokinesis by PP 1 and PP 2A
Here, we will review the evidence showing that mitotic exit is initiated by regulated
proteolysis and then driven by the PPP family of phosphoserine/threonine phosphatases …
proteolysis and then driven by the PPP family of phosphoserine/threonine phosphatases …
Protein phosphatases in the regulation of mitosis
J Nilsson - Journal of Cell Biology, 2019 - rupress.org
The accurate segregation of genetic material to daughter cells during mitosis depends on
the precise coordination and regulation of hundreds of proteins by dynamic phosphorylation …
the precise coordination and regulation of hundreds of proteins by dynamic phosphorylation …
[HTML][HTML] Phosphatases in mitosis: roles and regulation
Mitosis requires extensive rearrangement of cellular architecture and of subcellular
structures so that replicated chromosomes can bind correctly to spindle microtubules and …
structures so that replicated chromosomes can bind correctly to spindle microtubules and …
[HTML][HTML] Two interlinked bistable switches govern mitotic control in mammalian cells
Distinct protein phosphorylation levels in interphase and M phase require tight regulation of
Cdk1 activity [1, 2]. A bistable switch, based on positive feedback in the Cdk1 activation loop …
Cdk1 activity [1, 2]. A bistable switch, based on positive feedback in the Cdk1 activation loop …
[HTML][HTML] MASTL induces Colon Cancer progression and Chemoresistance by promoting Wnt/β-catenin signaling
Background Chemotherapeutic agents that modulate cell cycle checkpoints and/or tumor-
specific pathways have shown immense promise in preclinical and clinical studies aimed at …
specific pathways have shown immense promise in preclinical and clinical studies aimed at …
[HTML][HTML] Coordination of protein kinase and phosphoprotein phosphatase activities in mitosis
I Nasa, AN Kettenbach - Frontiers in cell and developmental biology, 2018 - frontiersin.org
Dynamic changes in protein phosphorylation govern the transitions between different
phases of the cell division cycle. A “tug of war” between highly conserved protein kinases …
phases of the cell division cycle. A “tug of war” between highly conserved protein kinases …
[HTML][HTML] Two bistable switches govern M phase entry
The abrupt and irreversible transition from interphase to M phase is essential to separate
DNA replication from chromosome segregation. This transition requires the switch-like …
DNA replication from chromosome segregation. This transition requires the switch-like …
[HTML][HTML] MASTL overexpression promotes chromosome instability and metastasis in breast cancer
MASTL kinase is essential for correct progression through mitosis, with loss of MASTL
causing chromosome segregation errors, mitotic collapse and failure of cytokinesis …
causing chromosome segregation errors, mitotic collapse and failure of cytokinesis …
[HTML][HTML] The role of canonical and non-canonical Hedgehog signaling in tumor progression in a mouse model of small cell lung cancer
A Szczepny, S Rogers, WSN Jayasekara, K Park… - Oncogene, 2017 - nature.com
Hedgehog (Hh) signaling regulates cell fate and self-renewal in development and cancer.
Canonical Hh signaling is mediated by Hh ligand binding to the receptor Patched (Ptch) …
Canonical Hh signaling is mediated by Hh ligand binding to the receptor Patched (Ptch) …
[HTML][HTML] Protein phosphatase 1 inactivates Mps1 to ensure efficient spindle assembly checkpoint silencing
Faithfull genome partitioning during cell division relies on the Spindle Assembly Checkpoint
(SAC), a conserved signaling pathway that delays anaphase onset until all chromosomes …
(SAC), a conserved signaling pathway that delays anaphase onset until all chromosomes …