Long considered both physiologic and inevitable, skin aging is a degenerative phenomenon
whereby both intrinsic and environmental factors conspire to produce an authentic disease …

The risk of onset of cancer is influenced by poorly controlled chronic inflammatory
processes. Inflammatory diseases related to cancer development include inflammatory …

Here we show that FTO as an N 6-methyladenosine (m6A) RNA demethylase is degraded
by selective autophagy, which is impaired by low-level arsenic exposure to promote …

Skin aging is a complex process, and alterations in human skin due to aging have distinct
characteristic as compared to other organs. The aging of dermal cells and the biological …

Exposure to ultraviolet (UV) radiation is associated with approximately 65% of melanoma
cases, and 90% of non-melanoma skin cancers (NMSC), including basal cell carcinoma …

Skin undergoes continuous renewal throughout an individual's lifetime relying on stem cell
functionality. However, a decline of the skin regenerative potential occurs with age. The …

Background Carcinogenesis is governed by a series of genetic alterations and epigenetic
changes that lead to aberrant patterns in neoplastic cells. Sirtuin-1 (SIRT1), an NAD+ …

SIRT6 is a SIR2 family member that regulates multiple molecular pathways involved in
metabolism, genomic stability, and aging. It has been proposed previously that SIRT6 is a …

Skin, as the outermost organ of the body, is constantly exposed to both intrinsic and extrinsic
causative factors of aging. Intrinsic aging is related to compromised cellular proliferative …

Hepatocellular carcinoma (HCC) is a highly aggressive liver tumor containing cancer stem
cells (CSCs), which participate in tumor invasion, therapeutic resistance, and tumor relapse …