[HTML][HTML] Exploiting replication gaps for cancer therapy
Defects in DNA double-strand break repair are thought to render BRCA1 or BRCA2 (BRCA)
mutant tumors selectively sensitive to PARP inhibitors (PARPis). Challenging this …
mutant tumors selectively sensitive to PARP inhibitors (PARPis). Challenging this …
Advances in understanding DNA processing and protection at stalled replication forks
K Rickman, A Smogorzewska - Journal of Cell Biology, 2019 - rupress.org
The replisome, the molecular machine dedicated to copying DNA, encounters a variety of
obstacles during S phase. Without a proper response to this replication stress, the genome …
obstacles during S phase. Without a proper response to this replication stress, the genome …
Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency
Mutations in BRCA1 or BRCA2 (BRCA) is synthetic lethal with poly (ADP-ribose)
polymerase inhibitors (PARPi). Lethality is thought to derive from DNA double-stranded …
polymerase inhibitors (PARPi). Lethality is thought to derive from DNA double-stranded …
HLTF promotes fork reversal, limiting replication stress resistance and preventing multiple mechanisms of unrestrained DNA synthesis
DNA replication stress can stall replication forks, leading to genome instability. DNA damage
tolerance pathways assist fork progression, promoting replication fork reversal, translesion …
tolerance pathways assist fork progression, promoting replication fork reversal, translesion …
Replication gaps underlie BRCA deficiency and therapy response
NJ Panzarino, JJ Krais, K Cong, M Peng, M Mosqueda… - Cancer research, 2021 - AACR
Defects in DNA repair and the protection of stalled DNA replication forks are thought to
underlie the chemosensitivity of tumors deficient in the hereditary breast cancer genes …
underlie the chemosensitivity of tumors deficient in the hereditary breast cancer genes …
Inhibition of the translesion synthesis polymerase REV1 exploits replication gaps as a cancer vulnerability
The replication stress response, which serves as an anticancer barrier, is activated not only
by DNA damage and replication obstacles but also oncogenes, thus obscuring how cancer …
by DNA damage and replication obstacles but also oncogenes, thus obscuring how cancer …
How do mutations affecting the breast cancer genes BRCA1 and BRCA2 cause cancer susceptibility?
AR Venkitaraman - DNA repair, 2019 - Elsevier
The inheritance of monoallelic germline mutations affecting BRCA1 or BRCA2 predisposes
with a high penetrance to several forms of epithelial malignancy. The large, nuclear …
with a high penetrance to several forms of epithelial malignancy. The large, nuclear …
History of DNA helicases
RM Brosh Jr, SW Matson - Genes, 2020 - mdpi.com
Since the discovery of the DNA double helix, there has been a fascination in understanding
the molecular mechanisms and cellular processes that account for:(i) the transmission of …
the molecular mechanisms and cellular processes that account for:(i) the transmission of …
The emerging determinants of replication fork stability
T Thakar, GL Moldovan - Nucleic acids research, 2021 - academic.oup.com
A universal response to replication stress is replication fork reversal, where the nascent
complementary DNA strands are annealed to form a protective four-way junction allowing …
complementary DNA strands are annealed to form a protective four-way junction allowing …
Loss of nuclear DNA ligase III reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by exposing ssDNA gaps
MP Dias, V Tripathi, I van der Heijden, K Cong… - Molecular cell, 2021 - cell.com
Inhibitors of poly (ADP-ribose)(PAR) polymerase (PARPi) have entered the clinic for the
treatment of homologous recombination (HR)-deficient cancers. Despite the success of this …
treatment of homologous recombination (HR)-deficient cancers. Despite the success of this …