The mammalian Slc4 (Solute carrier 4) family of transporters is a functionally diverse group
of 10 multi-spanning membrane proteins that includes three Cl-HCO3 exchangers (AE1–3) …

It is accepted that insulin-secreting β-cells release insulin in response to glucose even in the
absence of functional ATP-sensitive K+ (KATP)-channels, which play a central role in a …

Anions such as Cl− and HCO 3− are well known to play an important role in glucose-
stimulated insulin secretion (GSIS). In this study, we demonstrate that glucose-induced Cl …

Many cellular processes including neuronal activity are sensitive to changes in intracellular
and/or extracellular pH—both of which are regulated by acid–base transporter activity …

Low serum bicarbonate is closely related to type 2 diabetes mellitus. However, the precise
role of bicarbonate on glucose homeostasis and insulin secretion remains unknown. In this …

We examined membrane trafficking of NBCe1-A and NBCe1-B variants of the electrogenic
Na+-HCO3− cotransporter (NBCe1) encoded by the SLC4A4 gene, using confocal …

Background/aims: Stimulation of insulin release by D-glucose is accompanied by Cl-and
HCO3-efflux from pancreatic islet cells. The efflux of these anions may involve volume …

Glucose metabolism plays a crucial role in modulating glucagon secretion in pancreatic
alpha cells. However, the downstream effects of glucose metabolism and the activated …

Background/aims: The expression of the electrogenic Na+-HCO3--cotransporter NBCe1 was
recently documented in rat pancreatic islet B-cells, it being speculated that such a protein …

维持机体的酸碱稳态对各项生理活动的有序进行具有根本性的意义, 酸碱紊乱会导致一系列疾病
. 碳酸氢根(HCO3−) 是机体中最重要的酸碱缓冲离子. SLC4 家族的HCO3 …