The serine/threonine p21-activated kinases (PAKs), as main effectors of the Rho GTPases
Cdc42 and Rac, represent a group of important molecular switches linking the complex …

Dendrite morphology is pivotal for neural circuitry functioning. While the causative
relationship between small-scale dendrite morphological abnormalities (shape, density of …

Although the identification of numerous genes involved in neurodevelopmental disorders
(NDDs) has reshaped our understanding of their etiology, there are still major obstacles in …

Cortical GABAergic interneurons are critical components of neural networks. They provide
local and long-range inhibition and help coordinate network activities involved in various …

Description of robust transcriptomic alterations in Huntington's disease is essential to identify
targets for biochemical studies and drug development. We analysed publicly available …

Autism and epilepsy are diseases which have complex genetic inheritance. Genome-wide
association and other genetic studies have implicated at least 500+ genes associated with …

Mutations of PAK3, a p21-activated kinase, are associated in humans with cognitive deficits
suggestive of defective cortical circuits and with frequent brain structural abnormalities. Most …

Abnormalities in cortical interneurons are closely associated with neurological diseases.
Most patients with Foxg1 syndrome experience seizures, suggesting a possible role of …

The FoxM1 transcription factor plays an important role in the progression of HCC. Therefore,
it is necessary to study cell regulation of FoxM1. In this study, we determined the expression …

Although the pathogenesis of schizophrenia (SCZ) is proposed to involve alterations of
neural circuits via synaptic dysfunction, the underlying molecular mechanisms remain poorly …