This paper presents an overview of methods that have been proposed for the analysis of
breast cancer histopathology images. This research area has become particularly relevant …

Molecules that can specifically silence gene expression are powerful research tools. Much
effort has been put into the development of such molecules and has resulted in the creation …

The introduction of fast digital slide scanners that provide whole slide images has led to a
revival of interest in image analysis applications in pathology. Segmentation of cells and …

We present an extracellular matrix (ECM) microarray platform for the culture of patterned
cells atop combinatorial matrix mixtures. This platform enables the study of differentiation in …

RNA interference has re-energized the field of functional genomics by enabling genome-
scale loss-of-function screens in cultured cells. Looking back on the lessons that have been …

RNA interference (RNAi) has been very successfully applied as a gene-silencing technology
in both plants and invertebrates, but many practical obstacles need to be overcome before it …

By using genome information to create tools for perturbing gene function, it is now possible
to undertake systematic genome-wide functional screens that examine the contribution of …

Fluorescence microscopy combined with digital imaging constructs a basic platform for
numerous biomedical studies in the field of cellular imaging. As the studies relying on …

We describe a one-step method for creating thousands of isolated pico-to microliter-sized
droplets with defined geometry and volume. Arrays of droplets are instantly formed as liquid …

The complexity of human biology requires a systems approach that uses computational
approaches to integrate different data types. Systems biology encompasses the complete …