Abstract TriTryp diseases (Leishmaniasis, Human African Trypanosomiasis (HAT), and
Chagas disease) are devastating parasitic neglected tropical diseases (NTDs) that affect …

Tryptophan (Trp) metabolism involves three primary pathways: the kynurenine (Kyn)
pathway (KP), the 5-hydroxytryptamine (serotonin, 5-HT) pathway, and the indole pathway …

The oncogenic MUC1-C protein drives dedifferentiation of castrate resistant prostate cancer
(CRPC) cells in association with chromatin remodeling. The present work demonstrates that …

The epithelial barrier's primary role is to protect against entry of foreign and pathogenic
elements. Both COVID-19 and Inflammatory Bowel Disease (IBD) show commonalities in …

Transfer RNA dynamics contribute to cancer development through regulation of codon-
specific messenger RNA translation. Specific aminoacyl-tRNA synthetases can either …

Aminoacyl-tRNA synthetases (aaRSs) are essential enzymes responsible for linking a
transfer RNA (tRNA) with its cognate amino acid present in all the kingdoms of life. Besides …

Tryptophanyl-tRNA synthetase (WRS) is a critical enzyme involved in protein synthesis,
responsible for charging tRNA with the essential amino acid tryptophan. Recent studies …

Simple Summary Post-translational O-glycosylation of proteins with N-acetylglucosamine
serves as a cellular regulator that has been linked to cancer. This sugar's variability is …

The spatial position of cells within tissues and organs is crucial for the manifestation of their
specific functions. Spatial transcriptomics technology enables comprehensive measurement …

Globally, ovarian cancer (OC) ranks as a principal cause of cancer-related mortality in
females. Immunotherapy has revolutionized the treatment of OC, but the efficacy of …