Genetics meets proteomics: perspectives for large population-based studies
Proteomic analysis of cells, tissues and body fluids has generated valuable insights into the
complex processes influencing human biology. Proteins represent intermediate phenotypes …
complex processes influencing human biology. Proteins represent intermediate phenotypes …
A biosocial return to race? A cautionary view for the postgenomic era
Recent studies demonstrating epigenetic and developmental sensitivity to early
environments, as exemplified by fields like the Developmental Origins of Health and …
environments, as exemplified by fields like the Developmental Origins of Health and …
Structure annotation of all mass spectra in untargeted metabolomics
Urine metabolites are used in many clinical and biomedical studies but usually only for a few
classic compounds. Metabolomics detects vastly more metabolic signals that may be used to …
classic compounds. Metabolomics detects vastly more metabolic signals that may be used to …
Biosensors made of synthetic functional nucleic acids toward better human health
The invention of the in vitro selection technique, or SELEX (Systematic Evolution of Ligands
by EXponential enrichment), in the early 1990s, identified single-stranded (ss) nucleic acid …
by EXponential enrichment), in the early 1990s, identified single-stranded (ss) nucleic acid …
Elucidating the role of blood metabolites on pancreatic cancer risk using two‐sample Mendelian randomization analysis
Pancreatic ductal adenocarcinoma (PDAC) is an uncommon but highly fatal malignancy.
Identifying causal metabolite biomarkers offers an opportunity to facilitate effective risk …
Identifying causal metabolite biomarkers offers an opportunity to facilitate effective risk …
The emerging role of TXNIP in ischemic and cardiovascular diseases; a novel marker and therapeutic target
A Domingues, J Jolibois, P Marquet de Rougé… - International Journal of …, 2021 - mdpi.com
Thioredoxin interacting protein (TXNIP) is a metabolism-oxidative-and inflammation-related
marker induced in cardiovascular diseases and is believed to represent a possible link …
marker induced in cardiovascular diseases and is believed to represent a possible link …
Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits
SB Zaghlool, B Kühnel, MA Elhadad, S Kader… - Nature …, 2020 - nature.com
DNA methylation and blood circulating proteins have been associated with many complex
disorders, but the underlying disease-causing mechanisms often remain unclear. Here, we …
disorders, but the underlying disease-causing mechanisms often remain unclear. Here, we …
A roadmap to the molecular human linking multiomics with population traits and diabetes subtypes
In-depth multiomic phenotyping provides molecular insights into complex physiological
processes and their pathologies. Here, we report on integrating 18 diverse deep molecular …
processes and their pathologies. Here, we report on integrating 18 diverse deep molecular …
Lipid phenotypes and DNA methylation: a review of the literature
Abstract Purpose of Review Epigenetic modifications via DNA methylation have previously
been linked to blood lipid levels, dyslipidemias, and atherosclerosis. The purpose of this …
been linked to blood lipid levels, dyslipidemias, and atherosclerosis. The purpose of this …
[HTML][HTML] Lipidomes in health and disease: Analytical strategies and considerations
F Wei, S Lamichhane, M Orešič… - TrAC Trends in Analytical …, 2019 - Elsevier
Lipidomics is a rapidly-growing field which focuses on global characterization of lipids at
molecular and systems levels. As small changes in the concentrations of lipids may have …
molecular and systems levels. As small changes in the concentrations of lipids may have …