Flexible structural arrangement and DNA-binding properties of protein p6 from Bacillus subtillis phage φ29
M Alcorlo, JR Luque-Ortega, F Gago… - Nucleic Acids …, 2024 - academic.oup.com
The genome-organizing protein p6 of Bacillus subtilis bacteriophage φ29 plays an essential
role in viral development by activating the initiation of DNA replication and participating in …
role in viral development by activating the initiation of DNA replication and participating in …
Structural and mechanistic insight into DNA bending by antitumour calicheamicins
A Mills, F Gago - Organic & Biomolecular Chemistry, 2021 - pubs.rsc.org
Among the class of enediyne antibiotics endowed with potent antitumour activities, the
calicheamicin derivative known as ozogamicin is selectively targeted to several leukaemia …
calicheamicin derivative known as ozogamicin is selectively targeted to several leukaemia …
Sequence-dependent kink formation in short DNA loops: theory and molecular dynamics simulations
G Park, MK Cho, YJ Jung - Journal of Chemical Theory and …, 2021 - ACS Publications
Kink formation is essential in highly bent DNA complexed with gene regulatory proteins such
as histones to release the bending stress stored within the DNA duplex. Local opening of the …
as histones to release the bending stress stored within the DNA duplex. Local opening of the …
The N-terminal helix-turn-helix motif of transcription factors MarA and Rob drives DNA recognition
DNA-binding proteins play an important role in gene regulation and cellular function. The
transcription factors MarA and Rob are two homologous members of the AraC/XylS family …
transcription factors MarA and Rob are two homologous members of the AraC/XylS family …
Structural landscape of the transition from an ssDNA dumbbell plus its complementary hairpin to a dsDNA microcircle via a kissing loop intermediate
A Mills, F Gago - Molecules, 2021 - mdpi.com
The experimental construction of a double-stranded DNA microcircle of only 42 base pairs
entailed a great deal of ingenuity and hard work. However, figuring out the three …
entailed a great deal of ingenuity and hard work. However, figuring out the three …
Insight into the sequence-specific elements leading to increased DNA bending and ligase-mediated circularization propensity by antitumor trabectedin
A Mills, F Gago - Journal of Computer-Aided Molecular Design, 2021 - Springer
DNA curvature is the result of a combination of both intrinsic features of the double helix and
external distortions introduced by the environment and the binding of proteins or drugs. The …
external distortions introduced by the environment and the binding of proteins or drugs. The …
[PDF][PDF] SIMULACIONES POR ORDENADOR DE LAS INTERACCIONES FÁRMACO-ADN: UN VIAJE PERSONAL
FADN LAS INTERACCIONES - rafc.cat
El tema que he escogido para este discurso de ingreso es la relación-muy personal y
extendida en el tiempo-que he mantenido con el ácido desoxirribonucleico (ADN) y …
extendida en el tiempo-que he mantenido con el ácido desoxirribonucleico (ADN) y …