Modern genome-scale methods that identify new genes, such as proteogenomics and
ribosome profiling, have revealed, to the surprise of many, that overlap in genes, open …

Unlike the human genome that comprises mostly noncoding and regulatory sequences,
viruses have evolved under the constraints of maintaining a small genome size while …

Humans display substantial interindividual clinical variability after SARS-CoV-2 infection,–,
the genetic and immunological basis of which has begun to be deciphered. However, the …

Plant viruses with densely packed genomes employ noncanonical translational strategies to
increase the coding capacity for viral function. However, the diverse translational strategies …

There is considerable inter-individual and inter-population variability in response to viruses.
The potential of monocytes to elicit type-I interferon responses has attracted attention to their …

Genomic analyses in budding yeast have helped define the foundational principles of
eukaryotic gene expression. However, in the absence of empirical methods for defining …

RNA viruses are a major human health threat. The life cycles of many highly pathogenic
RNA viruses like influenza A virus (IAV) and Lassa virus depends on host mRNA, because …

MHC class I presentation of short peptides enables CD8+ T cell (T CD8+)
immunosurveillance of tumors and intracellular pathogens. A key feature of the class I …

Narnaviruses are RNA viruses detected in diverse fungi, plants, protists, arthropods, and
nematodes. Though initially described as simple single-gene nonsegmented viruses …

Epidemic and pandemic influenza A virus (IAV) poses a significant threat to human
populations worldwide. Iridoid glycosides are principal bioactive components from the …