The coronavirus disease 2019 (COVID-19) pandemic has elicited a swift response by the
scientific community to elucidate the pathogenesis of severe acute respiratory syndrome …

Dendritic cells (DCs) develop in the bone marrow from haematopoietic progenitors that have
numerous shared characteristics between mice and humans. Human counterparts of mouse …

Differentiation of proinflammatory CD4+ conventional T cells (T conv) is critical for productive
antitumor responses yet their elicitation remains poorly understood. We comprehensively …

Individuals suffering from severe viral respiratory tract infections have recently emerged as
“at risk” groups for developing invasive fungal infections. Influenza virus is one of the most …

Monocytes develop in the bone marrow and represent the primary type of mononuclear
phagocyte found in the blood. They were long thought of as a source for tissue …

Various lung insults can result in replacement of resident alveolar macrophages (AM) by
bone marrow monocyte–derived (BMo)–AM. However, the dynamics of this process and its …

Influenza A viruses (IAVs) are contagious pathogens responsible for severe respiratory
infection in humans and animals worldwide. Upon detection of IAV infection, host immune …

Dendritic cells have the ability to efficiently present internalized antigens on major
histocompatibility complex (MHC) I molecules. This process is termed cross-presentation …

Dendritic cells (DCs) are potent and versatile antigen-presenting cells, and their ability to
migrate is key for the initiation of protective pro-inflammatory as well as tolerogenic immune …

Microbial infections are recognized by the innate immune system both to elicit immediate
defense and to generate long-lasting adaptive immunity. To detect and respond to vastly …