A medicinal chemistry perspective on excitatory amino acid transporter 2 dysfunction in neurodegenerative diseases
The excitatory amino acid transporter 2 (EAAT2) plays a key role in the clearance and
recycling of glutamate-the major excitatory neurotransmitter in the mammalian brain. EAAT2 …
recycling of glutamate-the major excitatory neurotransmitter in the mammalian brain. EAAT2 …
Bridge between neuroimmunity and traumatic brain injury
ML Kelso, HE Gendelman - Current pharmaceutical design, 2014 - ingentaconnect.com
The pathophysiology of degenerative, infectious, inflammatory and traumatic diseases of the
central nervous system includes a significant immune component. As to the latter, damage to …
central nervous system includes a significant immune component. As to the latter, damage to …
Tonic activation of NMDA receptors by ambient glutamate of non‐synaptic origin in the rat hippocampus
KL Meur, M Galante, MC Angulo… - The Journal of …, 2007 - Wiley Online Library
In several neuronal types of the CNS, glutamate and GABA receptors mediate a persistent
current which reflects the presence of a low concentration of transmitters in the extracellular …
current which reflects the presence of a low concentration of transmitters in the extracellular …
[HTML][HTML] Astrocytes convert network excitation to tonic inhibition of neurons
Background Glutamate and γ-aminobutyric acid (GABA) transporters play important roles in
balancing excitatory and inhibitory signals in the brain. Increasing evidence suggest that …
balancing excitatory and inhibitory signals in the brain. Increasing evidence suggest that …
[HTML][HTML] Phosphorylation of tau at Y18, but not tau-fyn binding, is required for tau to modulate NMDA receptor-dependent excitotoxicity in primary neuronal culture
T Miyamoto, L Stein, R Thomas, B Djukic… - Molecular …, 2017 - Springer
Background Hyperexcitability of neuronal networks can lead to excessive release of the
excitatory neurotransmitter glutamate, which in turn can cause neuronal damage by …
excitatory neurotransmitter glutamate, which in turn can cause neuronal damage by …
[HTML][HTML] Glutamate uptake triggers transporter-mediated GABA release from astrocytes
Background Glutamate (Glu) and γ-aminobutyric acid (GABA) transporters play important
roles in regulating neuronal activity. Glu is removed from the extracellular space dominantly …
roles in regulating neuronal activity. Glu is removed from the extracellular space dominantly …
Rapid microelectrode measurements and the origin and regulation of extracellular glutamate in rat prefrontal cortex
J. Neurochem.(2010) 115, 1608–1620. Abstract Glutamate in the prefrontal cortex (PFC)
plays a significant role in several mental illnesses, including schizophrenia, addiction and …
plays a significant role in several mental illnesses, including schizophrenia, addiction and …
Disruptions in the regulation of extracellular glutamate by neurons and glia in the rat striatum two days after diffuse brain injury
JM Hinzman, TC Thomas, JE Quintero… - Journal of …, 2012 - liebertpub.com
Disrupted regulation of extracellular glutamate in the central nervous system contributes to
and can exacerbate the acute pathophysiology of traumatic brain injury (TBI). Previously, we …
and can exacerbate the acute pathophysiology of traumatic brain injury (TBI). Previously, we …
Inhibition of glutamate uptake in the spinal cord induces hyperalgesia and increased responses of spinal dorsal horn neurons to peripheral afferent stimulation
HR Weng, JH Chen, JP Cata - Neuroscience, 2006 - Elsevier
Glutamate is a primary excitatory neurotransmitter in the mammalian CNS. Glutamate
released from presynaptic neurons is cleared from the synaptic cleft passively by diffusion …
released from presynaptic neurons is cleared from the synaptic cleft passively by diffusion …
The role of excitatory amino acid transporters in cerebral ischemia
X Chao, F Fei, Z Fei - Neurochemical research, 2010 - Springer
Glutamate is an excitatory neurotransmitter that plays a major role in the pathogenesis of
ischemia brain injury. The regulation of glutamate neurotransmission is carried out by …
ischemia brain injury. The regulation of glutamate neurotransmission is carried out by …