Outer membrane lipid secretion and the innate immune response to gram-negative bacteria

NP Giordano, MB Cian, ZD Dalebroux - Infection and immunity, 2020 - Am Soc Microbiol
The outer membrane (OM) of Gram-negative bacteria is an asymmetric lipid bilayer that
consists of inner leaflet phospholipids and outer leaflet lipopolysaccharides (LPS). The …

[HTML][HTML] Bacterial biofilm inhibitors: An overview

VC Kalia, SKS Patel, JK Lee - Ecotoxicology and Environmental Safety, 2023 - Elsevier
Bacteria that cause infectious diseases adopt biofilms as one of their most prevalent
lifestyles. Biofilms enable bacteria to tolerate environmental stress and evade antibacterial …

Discovery of CFTR modulators for the treatment of cystic fibrosis

M Lopes-Pacheco, N Pedemonte… - Expert Opinion on Drug …, 2021 - Taylor & Francis
Introduction Cystic fibrosis (CF) is a life-threatening inherited disease caused by mutations
in the gene encoding the CF transmembrane conductance regulator (CFTR) protein, an …

Let-7b-5p in vesicles secreted by human airway cells reduces biofilm formation and increases antibiotic sensitivity of P. aeruginosa

K Koeppen, A Nymon, R Barnaby… - Proceedings of the …, 2021 - National Acad Sciences
Pseudomonas aeruginosa is an opportunistic pathogen that forms antibiotic-resistant
biofilms, which facilitate chronic infections in immunocompromised hosts. We have …

Extracellular vesicles and host–pathogen interactions: a review of inter-kingdom signaling by small noncoding RNA

BA Stanton - Genes, 2021 - mdpi.com
The focus of this brief review is to describe the role of noncoding regulatory RNAs, including
short RNAs (sRNA), transfer RNA (tRNA) fragments and microRNAs (miRNA) secreted in …

Drug-free cyclodextrin-based nanosponges for antimicrobial activity

D Desai, P Shende - Journal of Pharmaceutical Innovation, 2021 - Springer
Purpose Conventional and novel drug delivery systems encompass therapeutic effects for
treatment and management of various conditions like cancer, diabetes, and Alzheimer's …

Outer membrane vesicles from bacteria: Role and potential value in the pathogenesis of chronic respiratory diseases

F Han, W Wang, M Shi, H Zhou, Y Yao, C Li… - Frontiers in Cellular …, 2022 - frontiersin.org
Infectious diseases are the leading cause of death in both adults and children, with
respiratory infections being the leading cause of death. A growing body of evidence …

[HTML][HTML] Supramolecular assemblies based on polymeric cyclodextrin nanosponges and a cationic porphyrin with antimicrobial photodynamic therapy action

R Zagami, AR Pedrazzo, D Franco, F Caldera… - International Journal of …, 2023 - Elsevier
Within of the increasing requirement of alternative approaches to fight emerging infections,
nano-photosensitisers (nanoPS) are currently designed with the aim to optimize the …

The contribution of membrane vesicles to bacterial pathogenicity in cystic fibrosis infections and healthcare associated pneumonia

J Vitse, B Devreese - Frontiers in Microbiology, 2020 - frontiersin.org
Almost all bacteria secrete spherical membranous nanoparticles, also referred to as
membrane vesicles (MVs). A variety of MV types exist, ranging from 20 to 400 nm in …

[HTML][HTML] Design, Synthesis and Evaluation of Novel Antimicrobial Polymers Based on the Inclusion of Polyethylene Glycol/TiO2 Nanocomposites in Cyclodextrin as …

HM Dardeer, A Toghan, MEA Zaki, RB Elamary - Polymers, 2022 - mdpi.com
Polymers and their composites have recently attracted attention in both pharmaceutical and
biomedical applications. Polyethylene glycol (PEG) is a versatile polymer extensively used …