Ketamine, a racemic mixture consisting of (S)-and (R)-ketamine, has been in clinical use
since 1970. Although best characterized for its dissociative anesthetic properties, ketamine …

Global oxycodone consumption has increased sharply during the last two decades, and, in
2008, oxycodone consumption surpassed that of morphine. As oxycodone was synthesized …

Ketamine is commonly used as an analgesic in emergency medicine and as an adjuvant
drug in the perioperative setting. In addition, it is used as a third-line adjuvant drug for opioid …

Oxycodone, a semisynthetic derivative of naturally occurring thebaine, an opioid alkaloid,
has been available for more than 100 years. Although thebaine cannot be used …

Background: Severe pain often accompanies major spine surgery. Opioids are the
cornerstone of postoperative pain management but their use can be limited by numerous …

The drug ketamine has been extensively studied due to its use in anaesthesia, as a model of
psychosis and, most recently, its antidepressant properties. Understanding the physiology of …

Ketamine and its enantiomer S‐ketamine (esketamine) are known to produce rapid‐onset
antidepressant effects in major depression. Intranasal esketamine has recently come onto …

This review paper covers the forensic-relevant literature in controlled substances from 2016
to 2019 as a part of the 19th Interpol International Forensic Science Managers Symposium …

The NMDA receptor (NMDAR) antagonist ketamine has shown great potential as a rapid-
acting antidepressant; however, its use is limited by poor oral bioavailability and a side effect …

In the cancer pain setting, ketamine has been typically employed as a co-analgesic for
opioid refractory and neuropathic pain. One controversial topic is whether subanesthetic …