Clear cell renal cell carcinoma ontogeny and mechanisms of lethality
The molecular features that define clear cell renal cell carcinoma (ccRCC) initiation and
progression are being increasingly defined. The TRACERx Renal studies and others that …
progression are being increasingly defined. The TRACERx Renal studies and others that …
Akt in cancer: Mediator and more
S Revathidevi, AK Munirajan - Seminars in cancer biology, 2019 - Elsevier
Akt is a serine/threonine kinase and it participates in the key role of the PI3K signaling
pathway. The Akt can be activated by a wide range of growth signals and the biochemical …
pathway. The Akt can be activated by a wide range of growth signals and the biochemical …
Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations
J LoPiccolo, GM Blumenthal, WB Bernstein… - Drug Resistance …, 2008 - Elsevier
The PI3K/Akt/mTOR pathway is a prototypic survival pathway that is constitutively activated
in many types of cancer. Mechanisms for pathway activation include loss of tumor …
in many types of cancer. Mechanisms for pathway activation include loss of tumor …
Activation of AKT kinases in cancer: implications for therapeutic targeting
A Bellacosa, CC Kumar, A Di Cristofano… - Advances in cancer …, 2005 - Elsevier
The AKT1, AKT2, and AKT3 kinases have emerged as critical mediators of signal
transduction pathways downstream of activated tyrosine kinases and phosphatidylinositol 3 …
transduction pathways downstream of activated tyrosine kinases and phosphatidylinositol 3 …
Prognostic factors and predictive models in renal cell carcinoma: a contemporary review
M Sun, SF Shariat, C Cheng, V Ficarra, M Murai… - European urology, 2011 - Elsevier
CONTEXT: The natural history of renal cell carcinoma (RCC) is highly unpredictable. Small
renal masses may be accompanied by metastatic disease. Conversely, patients with locally …
renal masses may be accompanied by metastatic disease. Conversely, patients with locally …
[HTML][HTML] Kidney cancer biomarkers and targets for therapeutics: survivin (BIRC5), XIAP, MCL-1, HIF1α, HIF2α, NRF2, MDM2, MDM4, p53, KRAS and AKT in renal cell …
The incidence of renal cell carcinoma (RCC) is increasing worldwide with an approximate
20% mortality rate. The challenge in RCC is the therapy-resistance. Cancer resistance to …
20% mortality rate. The challenge in RCC is the therapy-resistance. Cancer resistance to …
A clearer view of the molecular complexity of clear cell renal cell carcinoma
IJ Frew, H Moch - Annual Review of Pathology: Mechanisms of …, 2015 - annualreviews.org
The von Hippel–Lindau (VHL) tumor suppressor gene is mutated as an early event in almost
all cases of clear cell renal cell carcinoma (ccRCC), the most frequent form of kidney cancer …
all cases of clear cell renal cell carcinoma (ccRCC), the most frequent form of kidney cancer …
The potential role of Akt phosphorylation in human cancers
J Cicenas - The International journal of biological markers, 2008 - journals.sagepub.com
Akt/protein kinase B (PKB) is a serine/threonine kinase which is implicated in mediating a
variety of biological responses including cell growth, proliferation and survival. Akt is …
variety of biological responses including cell growth, proliferation and survival. Akt is …
The phosphoinositide 3-kinase/Akt pathway: a new target in human renal cell carcinoma therapy
C Sourbier, V Lindner, H Lang, A Agouni, E Schordan… - Cancer research, 2006 - AACR
Metastatic renal cell carcinoma is resistant to current therapies. The phosphoinositide 3-
kinase (PI3K)/Akt signaling cascade induces cell growth, cell transformation, and …
kinase (PI3K)/Akt signaling cascade induces cell growth, cell transformation, and …
pVHL and PTEN tumour suppressor proteins cooperatively suppress kidney cyst formation
IJ Frew, CR Thoma, S Georgiev, A Minola, M Hitz… - The EMBO …, 2008 - embopress.org
In patients with von Hippel–Lindau (VHL) disease, renal cysts and clear cell renal cell
carcinoma (ccRCC) arise from renal tubular epithelial cells containing biallelic inactivation of …
carcinoma (ccRCC) arise from renal tubular epithelial cells containing biallelic inactivation of …