Pseudomonas aeruginosa is a complex gram-negative facultative anaerobe replete with a
variety of arsenals to activate, modify, and destroy host defense mechanisms. The microbe is …

Tryptophan metabolism, via the kynurenine (Kyn) pathway, and microbial transformation of
tryptophan to indolic compounds are fundamental for host health; both of which are altered …

Background Dysregulation of gut microbiota-associated tryptophan metabolism has been
observed in patients with multiple sclerosis. However, defining direct mechanistic links …

The link between gut microbiome and brain is being slowly acknowledged due to the
speculated role of resident gut microbial community in altering the functions of gut-brain axis …

The autoimmune disease systemic lupus erythematosus (SLE) is characterized by the
production of pathogenic autoantibodies. It has been postulated that gut microbial dysbiosis …

The aromatic amino acid L-tryptophan (Trp) is essentially metabolized along the host and
microbial pathways. While much is known about the role played by downstream metabolites …

The mosquito microbiota can influence host physiology and vector competence, but a
detailed understanding of these processes is lacking. Here we found that the gut microbiota …

Acinetobacter infections have high rates of mortality due to an increasing incidence of
infections by multidrug-resistant (MDR) and extensively-drug-resistant (XDR) strains …

The development of autoimmunity involves complex interactions between genetics and
environmental triggers. The gut microbiota is an important environmental constituent that …

In vitro culture media are being developed to understand how host site-specific nutrient
profiles influence microbial pathogenicity and ecology. To mimic the cystic fibrosis (CF) lung …