The conclusive identity of Wnts regulating liver zonation (LZ) and regeneration (LR) remains
unclear despite an undisputed role of β-catenin. Using single-cell analysis, we identified a …

Wnt proteins are secreted morphogens that play critical roles in embryonic development,
stem cell proliferation, self-renewal, tissue regeneration and remodeling in adults. While …

The process of metabolic liver zonation is spontaneously established by assigning
distributed tasks to hepatocytes along the porto-central blood flow. Hepatocytes fulfil critical …

Derangements of the blood-brain barrier (BBB) or blood-retinal barrier (BRB) occur in
disorders ranging from stroke, cancer, diabetic retinopathy, and Alzheimer's disease. The …

Background Wnt/β-catenin signaling is critical for lung development and AT2 stem cell
maintenance in adults, but excessive pathway activation has been associated with …

Selective and precise activation of signaling transduction cascades is key for cellular
reprogramming and tissue regeneration. However, the development of small-or large …

Purpose: There remains a high unmet need for therapies with new mechanisms of action to
achieve reperfusion of ischemic retina in diabetic retinopathy. We examined whether a novel …

Systemic toxicity is a major challenge in the development of therapeutics. Consequently, cell-
type-specific targeting is needed to improve on-target efficacy while reducing off-target …

The liver is uniquely bestowed with an ability to regenerate following a surgical or toxicant
insult. One of the most researched models to demonstrate the regenerative potential of this …

Molecules that facilitate targeted protein degradation (TPD) offer great promise as novel
therapeutics. The human hepatic lectin asialoglycoprotein receptor (ASGR) is selectively …