Circulating microRNAs in breast cancer: novel diagnostic and prognostic biomarkers

R Hamam, D Hamam, KA Alsaleh, M Kassem… - Cell death & …, 2017 - nature.com
Effective management of breast cancer depends on early diagnosis and proper monitoring
of patients' response to therapy. However, these goals are difficult to achieve because of the …

Methodological challenges in utilizing mi RNA s as circulating biomarkers

L Moldovan, KE Batte, J Trgovcich… - Journal of cellular …, 2014 - Wiley Online Library
Micro RNA s (mi RNA s) have emerged as important regulators in the post‐transcriptional
control of gene expression. The discovery of their presence not only in tissues but also in …

Novel combination of serum microRNA for detecting breast cancer in the early stage

A Shimomura, S Shiino, J Kawauchi… - Cancer …, 2016 - Wiley Online Library
MicroRNA (miRNA), which are stably present in serum, have been reported to be potentially
useful for detecting cancer. In the present study, we examined the expression profiles of …

Circulating miRNAs: roles in cancer diagnosis, prognosis and therapy

G Cheng - Advanced drug delivery reviews, 2015 - Elsevier
MicroRNAs (miRNAs) belong to a class of small non-coding RNAs that regulate numerous
biological processes by targeting a broad set of messenger RNAs. Recently, miRNAs have …

MiRNA and LncRNA as potential biomarkers in triple-negative breast cancer: a review

SR Volovat, C Volovat, I Hordila, DA Hordila… - Frontiers in …, 2020 - frontiersin.org
Noncoding RNAs (ncRNAs) include a diverse range of RNA species, including microRNAs
(miRNAs) and long noncoding RNAs (lncRNAs). MiRNAs, ncRNAs of approximately 19–25 …

Specific microRNA signatures in exosomes of triple-negative and HER2-positive breast cancer patients undergoing neoadjuvant therapy within the GeparSixto trial

I Stevic, V Müller, K Weber, PA Fasching, T Karn… - BMC medicine, 2018 - Springer
Background The focus of this study is to identify particular microRNA (miRNA) signatures in
exosomes derived from plasma of 435 human epidermal growth factor receptor 2 (HER2) …

A serum microRNA signature predicts tumor relapse and survival in triple-negative breast cancer patients

K Kleivi Sahlberg, G Bottai, B Naume, B Burwinkel… - Clinical cancer …, 2015 - AACR
Purpose: Triple-negative breast cancers (TNBC) are associated with high risk of early tumor
recurrence and poor outcome. Common prognostic biomarkers give very restricted …

Development and validation of a circulating microRNA panel for the early detection of breast cancer

R Zou, SY Loke, YC Tang, HP Too, L Zhou… - British journal of …, 2022 - nature.com
Background Mammography is widely used for breast cancer screening but suffers from a
high false-positive rate. Here, we perform the largest comprehensive, multi-center study to …

Plasma DNA integrity as a biomarker for primary and metastatic breast cancer and potential marker for early diagnosis

D Madhavan, M Wallwiener, K Bents… - Breast cancer research …, 2014 - Springer
Circulating or cell-free DNA (cfDNA) has been evaluated as a biomarker in many cancers
including breast cancer. In particular, integrity of cfDNA has been shown to be altered in …

Molecular links between central obesity and breast cancer

AA Zimta, AB Tigu, M Muntean, D Cenariu… - International journal of …, 2019 - mdpi.com
Worldwide, breast cancer (BC) is the most common malignancy in women, in regard to
incidence and mortality. In recent years, the negative role of obesity during BC development …