Stem cell systems regulate tissue development and maintenance. The germline stem cell
system is essential for animal reproduction, controlling both the timing and number of …

DNA must be accurately copied and propagated from one cell division to the next, and from
one generation to the next. To ensure the faithful transmission of the genome, a plethora of …

Kinase translocation reporters (KTRs) are genetically encoded fluorescent activity sensors
that convert kinase activity into a nucleocytoplasmic shuttling equilibrium for visualizing …

The responses of different organs are important for organisms against the toxicity of
environmental toxicants. So far, the neuronal response to nanoplastic exposure and the …

Central questions in regenerative biology include how stem cells are maintained and how
they transition from self-renewal to differentiation. Germline stem cells (GSCs) in Caeno …

Developmental programs are executed by tightly controlled gene regulatory pathways. Here,
we combined the unique sample retrieval capacity afforded by laser capture microscopy with …

Cell death plays a major role during C. elegans oogenesis, where over half of the oogenic
germ cells die in a process termed physiological apoptosis. How germ cells are selected for …

During oogenesis, oocytes arrest at meiotic prophase I to acquire competencies for
resuming meiosis, fertilization, and early embryonic development. Following this arrested …

Abstract Receptor Tyrosine Kinase (RTK)-Ras-Extracellular signal-regulated kinase (ERK)
signaling pathways control many aspects of C. elegans development and behavior. Studies …

In sexually reproducing animals, oocytes arrest at diplotene or diakinesis and resume
meiosis (meiotic maturation) in response to hormones. Chromosome segregation errors in …