Prostate cancer is the most frequent nonskin cancer and second most common cause of
cancer-related deaths in man. Prostate cancer is a clinically heterogeneous disease with …

Lineage plasticity and histologic transformation to small cell neuroendocrine prostate cancer
(NEPC) is an increasingly recognized mechanism of treatment resistance in advanced …

In castration-resistant prostate cancer (CRPC), the loss of androgen receptor (AR)
dependence leads to clinically aggressive tumors with few therapeutic options. We used …

Lineage plasticity has emerged as an important mechanism of treatment resistance in
prostate cancer. Treatment-refractory prostate cancers are increasingly associated with loss …

Abstract Treatment of prostate cancer (PC) by androgen suppression promotes the
emergence of aggressive variants that are androgen receptor (AR) independent. Here we …

Abstract Analysis of DNA methylation is a valuable tool to understand disease progression
and is increasingly being used to create diagnostic and prognostic clinical biomarkers …

Intestinal organoids accurately recapitulate epithelial homeostasis in vivo, thereby
representing a powerful in vitro system to investigate lineage specification and cellular …

Chemotherapy and radiation not only trigger cancer cell apoptosis but also damage stromal
cells in the tumour microenvironment (TME), inducing a senescence-associated secretory …

Hepatocyte Nuclear Factor 4 (HNF4) is a transcription factor (TF) belonging to the nuclear
receptor family whose expression and activities are restricted to a limited number of organs …

Chromosomal rearrangements resulting in the fusion of TMPRSS2, an androgen-regulated
gene, and the ETS family transcription factor ERG occur in over half of prostate cancers …