Protein lysine deacetylases have a pivotal role in numerous biological processes and can
be divided into the Rpd3/Hda1 and sirtuin families, each having members in diverse …

Zinc binding groups (ZBGs) play a crucial role in targeting histone deacetylase inhibitors
(HDACIs) to the active site of histone deacetylases (HDACs), thus determining the potency …

Histone deacetylases (HDACs) and histone acetyl transferases (HATs) are two
counteracting enzyme families whose enzymatic activity controls the acetylation state of …

Eukaryotic genomes are packaged into chromatin, a highly organized structure consisting of
DNA and histone proteins. All nuclear processes take place in the context of chromatin …

The interest in histone deacetylase (HDACa) inhibitors began almost 30 years ago during
some studies designed to understand why dimethyl sulfoxide (DMSO) caused terminal …

Known histone deacetylases (HDACs) are divided into different classes, and HDAC3
belongs to Class I. Through forming multiprotein complexes with the corepressors SMRT …

Sin3, a large acidic protein, shares structural similarity with the helix-loop-helix dimerization
domain of proteins of the Myc family of transcription factors. Sin3/HDAC corepressor …

The myocyte enhancer factor 2 (MEF2) family of transcription factors is not only important for
controlling gene expression in normal cellular programs, like muscle differentiation, T-cell …

The elucidation of mechanisms of chromatin remodeling, particular transcriptional activation,
and repression by histone acetylation and deacetylation has shed light on the role of histone …

Pharmacological inhibition of histone deacetylases (HDACs) has been successfully applied
in the treatment of a wide range of disorders, including Parkinson's disease, infection …