Gametogenesis, the process of forming mature germ cells, is an integral part of both an
individual's and a species' health and well-being. This chapter focuses on critical male and …

Meiosis is a specialized cell division that generates haploid gametes and is critical for
successful sexual reproduction. During the extended meiotic prophase I, homologous …

In brief Proper development of ovarian follicles, comprised of an oocyte and surrounding
somatic cells, is essential to support female fertility and endocrine health. Here, we describe …

Meiosis is critical to generating oocytes and ensuring female fertility; however, the
mechanisms regulating the switch from mitotic primordial germ cells to meiotic germ cells …

In most animals, the oocyte is the largest cell by volume. The oocyte undergoes a period of
large-scale growth during its development, prior to fertilization. At first glance, tissues that …

Mammalian females are born with a finite reserve of ovarian follicles, the functional units of
the ovary. Building an ovarian follicle involves a complex interaction between multiple cell …

The ovary is an indispensable unit of female reproduction and health. However, the study of
ovarian function in mammals is hindered by unique challenges, which include the …

Testes and ovaries undergo sex-specific morphogenetic changes and adopt strikingly
different morphologies, despite the fact that both arise from a common precursor, the …

Morphogenetic events during the development of the fetal ovary are crucial to the
establishment of female fertility. However, the effects of structural rearrangements of the …

Comparative studies of primordial germ cell (PGC) development across organisms in many
phyla reveal surprising diversity in the route of migration, timing and underlying molecular …