Immune system regulation is of paramount importance to host survival. In settings of
autoimmunity and alloimmunity, control is lost, resulting in injury to vital organs and tissues …

Regulatory T cells (Tregs) are essential to transplantation tolerance and their therapeutic
efficacy is well documented in animal models. Moreover, human Tregs can be identified …

Regulatory T (T reg) cells are critical regulators of immune tolerance. Most T reg cells are
defined based on expression of CD4, CD25, and the transcription factor, FoxP3. However …

Abstract Interleukin-2 (IL-2) is historically known as a T-cell growth factor. Accumulating
evidence from knockout mice suggests that IL-2 is crucial for the homeostasis and function of …

Abstract Thymus-derived CD4+ CD25+ regulatory T cells suppress autoreactive CD4+ and
CD8+ T cells and thereby protect from autoimmunity. In animal models, adoptive transfer of …

It has been reported that an increased population of regulatory T cells (Tregs) is one of the
reasons for impaired anti‐tumor immunity. Recently, Foxp3 has been reported as a reliable …

Background aims Mouse models indicate that adoptive transfer of regulatory T cells (Treg)
may suppress graft-versus-host-disease (GvHD) while preserving graft-versus-leukemia …

The forkhead family protein FOXP3 acts as a repressor of transcription and is both an
essential and sufficient regulator of the development and function of regulatory T cells. The …

Regulatory T cells (Tregs) suppress exuberant immune system activation and promote
immunologic tolerance. Because Tregs modulate both innate and adaptive immunity, the …

Although quantitative identification and viable enrichment of natural regulatory T cells (T-
regs) in humans are problematic, such steps would greatly facilitate the analysis of these …