Recent progress in Lyme disease and remaining challenges
Lyme disease (also known as Lyme borreliosis) is the most common vector-borne disease in
the United States with an estimated 476,000 cases per year. While historically, the long-term …
the United States with an estimated 476,000 cases per year. While historically, the long-term …
Immune response to Borrelia: lessons from Lyme disease spirochetes
LK Bockenstedt, RM Wooten, N Baumgarth - Current issues in molecular …, 2021 - mdpi.com
The mammalian host responds to infection with Borrelia spirochetes through a highly
orchestrated immune defense involving innate and adaptive effector functions aimed toward …
orchestrated immune defense involving innate and adaptive effector functions aimed toward …
Specific integration of temperate phage decreases the pathogenicity of host bacteria
Y Chen, L Yang, D Yang, J Song, C Wang… - Frontiers in Cellular …, 2020 - frontiersin.org
Temperate phages are considered as natural vectors for gene transmission among bacteria
due to the ability to integrate their genomes into a host chromosome, therefore, affect the …
due to the ability to integrate their genomes into a host chromosome, therefore, affect the …
Interception proximity labeling for interrogating cell efflux microenvironment
G Wang, Q Li, Y Guo, L Chen, Y Yao, Y Zhong… - Analytical …, 2023 - ACS Publications
The difficulty in elucidating the microenvironment of extracellular H2O2 efflux has led to the
lack of a critical extracellular link in studies of the mechanisms of redox signaling pathways …
lack of a critical extracellular link in studies of the mechanisms of redox signaling pathways …
Targeting tumor-associated macrophages for cancer immunotherapy
Tumor-associated macrophages (TAMs) are one of the most abundant immune components
in the tumor microenvironment and play a plethora of roles in regulating tumorigenesis …
in the tumor microenvironment and play a plethora of roles in regulating tumorigenesis …
Immunomodulatory activity of Senegalia macrostachya (Reichenb. ex DC.) Kyal. & Boatwr seed polysaccharide fraction through the activation of the MAPK signaling …
Senegalia macrostachya (Reichenb. ex DC.) Kyal. & Boatwr seed (SMS) is a wild legume
used as food and medicine in many African countries. In the current study, a novel …
used as food and medicine in many African countries. In the current study, a novel …
Lyme Disease Agent Reservoirs Peromyscus leucopus and P. maniculatus Have Natively Inactivated Genes for the High-Affinity Immunoglobulin Gamma Fc …
AG Barbour, JV Duong, AD Long - Pathogens, 2023 - mdpi.com
The abundant and widely distributed deermice Peromyscus leucopus and P. maniculatus
are important reservoirs for several different zoonotic agents in North America. For the …
are important reservoirs for several different zoonotic agents in North America. For the …
Molecular Mechanisms of Borrelia burgdorferi Phagocytosis and Intracellular Processing by Human Macrophages
P Woitzik, S Linder - Biology, 2021 - mdpi.com
Simple Summary Borreliae are a group of highly motile bacteria that are characterized by
their corkscrew-like shape. They can be transferred by a tick bite to a human host and cause …
their corkscrew-like shape. They can be transferred by a tick bite to a human host and cause …
A combined transcriptomic approach to identify candidates for an anti-tick vaccine blocking B. afzelii transmission
JJA Trentelman, R Sima, N Krezdorn… - Scientific reports, 2020 - nature.com
Ixodes ricinus is the vector for Borrelia afzelii, the predominant cause of Lyme borreliosis in
Europe, whereas Ixodes scapularis is the vector for Borrelia burgdorferi in the USA …
Europe, whereas Ixodes scapularis is the vector for Borrelia burgdorferi in the USA …
The commensal bacterium Lactiplantibacillus plantarum imprints innate memory-like responses in mononuclear phagocytes
A Pellon, D Barriales, A Peña-Cearra… - Gut …, 2021 - Taylor & Francis
Gut microbiota is a constant source of antigens and stimuli to which the resident immune
system has developed tolerance. However, the mechanisms by which mononuclear …
system has developed tolerance. However, the mechanisms by which mononuclear …