Recent progress in Lyme disease and remaining challenges

JR Bobe, BL Jutras, EJ Horn, ME Embers… - Frontiers in …, 2021 - frontiersin.org
Lyme disease (also known as Lyme borreliosis) is the most common vector-borne disease in
the United States with an estimated 476,000 cases per year. While historically, the long-term …

Immune response to Borrelia: lessons from Lyme disease spirochetes

LK Bockenstedt, RM Wooten, N Baumgarth - Current issues in molecular …, 2021 - mdpi.com
The mammalian host responds to infection with Borrelia spirochetes through a highly
orchestrated immune defense involving innate and adaptive effector functions aimed toward …

Specific integration of temperate phage decreases the pathogenicity of host bacteria

Y Chen, L Yang, D Yang, J Song, C Wang… - Frontiers in Cellular …, 2020 - frontiersin.org
Temperate phages are considered as natural vectors for gene transmission among bacteria
due to the ability to integrate their genomes into a host chromosome, therefore, affect the …

Interception proximity labeling for interrogating cell efflux microenvironment

G Wang, Q Li, Y Guo, L Chen, Y Yao, Y Zhong… - Analytical …, 2023 - ACS Publications
The difficulty in elucidating the microenvironment of extracellular H2O2 efflux has led to the
lack of a critical extracellular link in studies of the mechanisms of redox signaling pathways …

Targeting tumor-associated macrophages for cancer immunotherapy

X Cao, SWT Lai, S Chen, S Wang, M Feng - International Review of Cell …, 2022 - Elsevier
Tumor-associated macrophages (TAMs) are one of the most abundant immune components
in the tumor microenvironment and play a plethora of roles in regulating tumorigenesis …

Immunomodulatory activity of Senegalia macrostachya (Reichenb. ex DC.) Kyal. & Boatwr seed polysaccharide fraction through the activation of the MAPK signaling …

AWS Zongo, D Zogona, Z Zhang, M Youssef, P Zhou… - Food & Function, 2022 - pubs.rsc.org
Senegalia macrostachya (Reichenb. ex DC.) Kyal. & Boatwr seed (SMS) is a wild legume
used as food and medicine in many African countries. In the current study, a novel …

Lyme Disease Agent Reservoirs Peromyscus leucopus and P. maniculatus Have Natively Inactivated Genes for the High-Affinity Immunoglobulin Gamma Fc …

AG Barbour, JV Duong, AD Long - Pathogens, 2023 - mdpi.com
The abundant and widely distributed deermice Peromyscus leucopus and P. maniculatus
are important reservoirs for several different zoonotic agents in North America. For the …

Molecular Mechanisms of Borrelia burgdorferi Phagocytosis and Intracellular Processing by Human Macrophages

P Woitzik, S Linder - Biology, 2021 - mdpi.com
Simple Summary Borreliae are a group of highly motile bacteria that are characterized by
their corkscrew-like shape. They can be transferred by a tick bite to a human host and cause …

A combined transcriptomic approach to identify candidates for an anti-tick vaccine blocking B. afzelii transmission

JJA Trentelman, R Sima, N Krezdorn… - Scientific reports, 2020 - nature.com
Ixodes ricinus is the vector for Borrelia afzelii, the predominant cause of Lyme borreliosis in
Europe, whereas Ixodes scapularis is the vector for Borrelia burgdorferi in the USA …

The commensal bacterium Lactiplantibacillus plantarum imprints innate memory-like responses in mononuclear phagocytes

A Pellon, D Barriales, A Peña-Cearra… - Gut …, 2021 - Taylor & Francis
Gut microbiota is a constant source of antigens and stimuli to which the resident immune
system has developed tolerance. However, the mechanisms by which mononuclear …