Proteins are inherently flexible at ambient temperature. At equilibrium, they are
characterized by a set of conformations that undergo continuous exchange within a …

Magnetic resonance imaging (MRI) has been immensely valuable in diagnostic clinical
imaging over the last few decades owing to its exceptional spatial and anatomical …

The study of chemical exchange processes is one of the oldest and still most vigorously
investigated topics in NMR spectroscopy. The effects of chemical exchange on the NMR …

Time-dependent dynamical properties of molecules can be quantified with atomic resolution
by using solution-state NMR spectroscopy. A variety of NMR observables, including scalar …

Chemical exchange observed by NMR saturation transfer (CEST) and spin‐lock (SL)
experiments provide an MRI contrast by indirect detection of exchanging protons. The …

Purpose Chemical exchange sensitive spin‐lock and related techniques allow to observe
the uptake of administered D‐glucose in vivo. The exchange‐weighting increases with the …

The phenomenon of chemical or conformational exchange in NMR spectroscopy has
enabled detailed characterization of time-dependent aspects of biomolecular function …

Postmortem demonstration of increased iron in the substantia nigra (SN) is a well‐
appreciated finding in Parkinson's disease (PD). Iron facilitates generation of free radicals …

Purpose To evaluate the sensitivity of quantitative MRI techniques (T1, T1, Gd, T2, continous
wave (CW) T1ρ dispersion, adiabatic T1ρ, adiabatic T2ρ, RAFF and inversion‐prepared …

A new method to measure rotating frame relaxation and to create contrast for MRI is
introduced. The technique exploits relaxation along a fictitious field (RAFF) generated by …