Abstract NEDD4-2 (also known as NEDD4L, neural precursor cell expressed
developmentally down-regulated 4-like) is a ubiquitin protein ligase of the Nedd4 family …

CFTR biogenesis starts with its co-translational insertion into the membrane of endoplasmic
reticulum and folding of the cytosolic domains, towards the acquisition of a fully folded …

Ion channels (IChs) are transmembrane proteins that selectively drive ions across
membranes. The function of IChs partially relies on their abundance and proper location in …

The cystic fibrosis transmembrane conductance regulator (CFTR) and the amiloride-
sensitive epithelial sodium channels (ENaC) are located in the apical membranes of airway …

Potassium channels are multi-subunit transmembrane proteins that permit the selective
passage of potassium and play fundamental roles in physiological processes, such as …

Conformationally defective cystic fibrosis transmembrane conductance regulator (CFTR)
including rescued ΔF508-CFTR is rapidly eliminated from the plasma membrane (PM) even …

The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-regulated
chloride (Cl−) channel. Mutations of its gene lead to the disease of cystis fibrosis (CF) …

Neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein
ligase (Nedd4-1 and Nedd4-2) is a member of the HECT E3 ubiquitin ligase family. It has …

The ΔF508 mutant form of the cystic fibrosis transmembrane conductance regulator (ΔF508
CFTR) that is normally degraded by the ER-associated degradative pathway can be rescued …

Ion channels and transporters play essential roles in excitable cells including cardiac,
skeletal, and smooth muscle cells, neurons, and endocrine cells. Their dysfunction underlies …