Merkel cell polyomavirus (MCPyV) is a small DNA virus with oncogenic potential. MCPyV is
the causative agent of Merkel Cell Carcinoma (MCC), a rare but aggressive tumor of the …

Merkel Cell Carcinoma (MCC) is a rare but highly aggressive form of non–melanoma skin
cancer whose 5-year survival rate is 63%. Merkel cell polyomavirus (MCPyV), a small DNA …

Enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase and emerging
therapeutic target that is overexpressed in most castration-resistant prostate cancers and …

It is critical that epiblast cells within blastocyst-stage embryos receive the necessary
regulatory cues to remain pluripotent until the appropriate time when they are stimulated to …

The eukaryotic epigenome has an instrumental role in determining and maintaining cell
identity and function. Epigenetic components such as DNA methylation, histone tail …

Stability of the epigenetic landscape underpins maintenance of the cell-type-specific
transcriptional profile. As one of the main repressive epigenetic systems, DNA methylation …

Wnt signaling usually functions through a spatial gradient. Localized Wnt3a signaling can
induce the asymmetric division of mouse embryonic stem cells, where proximal daughter …

Recent advances in single-cell sequencing technologies have enabled simultaneous
measurement of multiple cellular modalities, but the combined detection of histone post …

Pluripotent embryonic stem cells (ESCs) are considered to have open and accessible
chromatin relative to differentiated cells. However, as many studies supporting these …

Recent studies have indicated that nucleosome turnover is rapid, occurring several times
per cell cycle. To access the effect of nucleosome turnover on the epigenetic landscape, we …