Mechanisms of antibody-dependent enhancement of infectious disease

TJ Wells, T Esposito, IR Henderson… - Nature Reviews …, 2024 - nature.com
Antibody-dependent enhancement (ADE) of infectious disease is a phenomenon whereby
host antibodies increase the severity of an infection. It is well established in viral infections …

Evolving understanding of autoimmune mechanisms and new therapeutic strategies of autoimmune disorders

Y Song, J Li, Y Wu - Signal Transduction and Targeted Therapy, 2024 - nature.com
Autoimmune disorders are characterized by aberrant T cell and B cell reactivity to the body's
own components, resulting in tissue destruction and organ dysfunction. Autoimmune …

[HTML][HTML] Human cerebrospinal fluid monoclonal CASPR2 autoantibodies induce changes in electrophysiology, functional MRI, and behavior in rodent models

S van Hoof, J Kreye, C Cordero-Gómez… - Brain, Behavior, and …, 2024 - Elsevier
Anti-contactin associated protein receptor 2 (CASPR2) encephalitis is a severe autoimmune
encephalitis with a variable clinical phenotype including behavioral abnormalities, cognitive …

Epitope landscape in autoimmune neurological disease and beyond

I Talucci, HM Maric - Trends in Pharmacological Sciences, 2024 - cell.com
Autoantibody binding has a central role in autoimmune diseases and has also been linked
to cancer, infections, and behavioral disorders. Autoimmune neurological diseases remain …

Predicting the future of autoimmune encephalitides

M Guasp, J Dalmau - Revue Neurologique, 2024 - Elsevier
The concept that many neurologic and psychiatric disorders of unknown cause are immune-
mediated has evolved fast during the past 20 years. The main contribution to the expansion …

Novel and Emerging Treatments to Target Pathophysiological Mechanisms in Various Phenotypes of Multiple Sclerosis

G Bsteh, A Dal Bianco, T Zrzavy, T Berger - Pharmacological Reviews, 2024 - ASPET
The objective is to comprehensively review novel pharmacotherapies used in multiple
sclerosis (MS) and the possibilities they may carry for therapeutic improvement. Specifically …

Immunotherapy strategy for systemic autoimmune diseases: betting on CAR-T cells and antibodies

V Chasov, E Zmievskaya, I Ganeeva, E Gilyazova… - Antibodies, 2024 - mdpi.com
Systemic autoimmune diseases (SAIDs), such as systemic lupus erythematosus (SLE),
systemic sclerosis (SSc) and rheumatoid arthritis (RA), are fully related to the unregulated …

The immunology underlying CNS autoantibody diseases

J Cleaver, B Ceronie, C Strippel, A Handel, SR Irani - Revue Neurologique, 2024 - Elsevier
The past two decades have seen a considerable paradigm shift in the way autoimmune
CNS disorders are considered, diagnosed, and treated; largely due to the discovery of novel …

Sequential immunotherapy: towards cures for autoimmunity

F Ramírez-Valle, JC Maranville, S Roy… - Nature Reviews Drug …, 2024 - nature.com
Despite major progress in the treatment of autoimmune diseases in the past two decades,
most therapies do not cure disease and can be associated with increased risk of infection …

Precise recognition of benzonitrile derivatives with supramolecular macrocycle of phosphorylated cavitand by co-crystallization method

H Li, Z Li, C Lin, J Jiang, L Wang - Nature Communications, 2024 - nature.com
The importance of molecular docking in drug discovery lies in the precise recognition
between potential drug compounds and their target receptors, which is generally based on …