Mechanisms of antibody-dependent enhancement of infectious disease
TJ Wells, T Esposito, IR Henderson… - Nature Reviews …, 2024 - nature.com
Antibody-dependent enhancement (ADE) of infectious disease is a phenomenon whereby
host antibodies increase the severity of an infection. It is well established in viral infections …
host antibodies increase the severity of an infection. It is well established in viral infections …
Evolving understanding of autoimmune mechanisms and new therapeutic strategies of autoimmune disorders
Y Song, J Li, Y Wu - Signal Transduction and Targeted Therapy, 2024 - nature.com
Autoimmune disorders are characterized by aberrant T cell and B cell reactivity to the body's
own components, resulting in tissue destruction and organ dysfunction. Autoimmune …
own components, resulting in tissue destruction and organ dysfunction. Autoimmune …
[HTML][HTML] Human cerebrospinal fluid monoclonal CASPR2 autoantibodies induce changes in electrophysiology, functional MRI, and behavior in rodent models
S van Hoof, J Kreye, C Cordero-Gómez… - Brain, Behavior, and …, 2024 - Elsevier
Anti-contactin associated protein receptor 2 (CASPR2) encephalitis is a severe autoimmune
encephalitis with a variable clinical phenotype including behavioral abnormalities, cognitive …
encephalitis with a variable clinical phenotype including behavioral abnormalities, cognitive …
Epitope landscape in autoimmune neurological disease and beyond
Autoantibody binding has a central role in autoimmune diseases and has also been linked
to cancer, infections, and behavioral disorders. Autoimmune neurological diseases remain …
to cancer, infections, and behavioral disorders. Autoimmune neurological diseases remain …
Predicting the future of autoimmune encephalitides
M Guasp, J Dalmau - Revue Neurologique, 2024 - Elsevier
The concept that many neurologic and psychiatric disorders of unknown cause are immune-
mediated has evolved fast during the past 20 years. The main contribution to the expansion …
mediated has evolved fast during the past 20 years. The main contribution to the expansion …
Novel and Emerging Treatments to Target Pathophysiological Mechanisms in Various Phenotypes of Multiple Sclerosis
The objective is to comprehensively review novel pharmacotherapies used in multiple
sclerosis (MS) and the possibilities they may carry for therapeutic improvement. Specifically …
sclerosis (MS) and the possibilities they may carry for therapeutic improvement. Specifically …
Immunotherapy strategy for systemic autoimmune diseases: betting on CAR-T cells and antibodies
Systemic autoimmune diseases (SAIDs), such as systemic lupus erythematosus (SLE),
systemic sclerosis (SSc) and rheumatoid arthritis (RA), are fully related to the unregulated …
systemic sclerosis (SSc) and rheumatoid arthritis (RA), are fully related to the unregulated …
The immunology underlying CNS autoantibody diseases
The past two decades have seen a considerable paradigm shift in the way autoimmune
CNS disorders are considered, diagnosed, and treated; largely due to the discovery of novel …
CNS disorders are considered, diagnosed, and treated; largely due to the discovery of novel …
Sequential immunotherapy: towards cures for autoimmunity
F Ramírez-Valle, JC Maranville, S Roy… - Nature Reviews Drug …, 2024 - nature.com
Despite major progress in the treatment of autoimmune diseases in the past two decades,
most therapies do not cure disease and can be associated with increased risk of infection …
most therapies do not cure disease and can be associated with increased risk of infection …
Precise recognition of benzonitrile derivatives with supramolecular macrocycle of phosphorylated cavitand by co-crystallization method
H Li, Z Li, C Lin, J Jiang, L Wang - Nature Communications, 2024 - nature.com
The importance of molecular docking in drug discovery lies in the precise recognition
between potential drug compounds and their target receptors, which is generally based on …
between potential drug compounds and their target receptors, which is generally based on …