In patients with diabetes, myocardial fibrosis may contribute to the pathogenesis of heart
failure and arrhythmogenesis, increasing ventricular stiffness and delaying conduction …

In the lungs, fibrosis is a growing clinical problem that results in shortness of breath and can
end up in respiratory failure. Even though the main fibrotic disease affecting the lung is …

Background: Conversion of cardiac stromal cells into myofibroblasts is typically associated
with hypoxia conditions, metabolic insults, and/or inflammation, all of which are predisposing …

Background Cardiac remodeling is one of the major risk factors for heart failure. In patients
with type 2 diabetes, sodium–glucose cotransporter 2 (SGLT2) inhibitors reduce the risk of …

Cardiac fibrosis is a common pathological consequence of most myocardial diseases. It is
associated with the excessive accumulation of extracellular matrix proteins as well as …

Cardiac fibrosis is characterized by a maladaptive remodeling of the myocardium, which is
controlled by various inflammatory pathways and cytokines. This remodeling is …

Diabetic cardiomyopathy (DCM), a main cardiovascular complication of diabetes, can
eventually develop into heart failure and affect the prognosis of patients. Myocardial fibrosis …

Background Excessive myocardial fibrosis is the pathological basis of heart failure following
myocardial infarction (MI). Although calycosin improves cardiac function, its effect on cardiac …

Cardiac fibrosis is characteristic of the end stage in nearly all forms of heart disease.
Accumulation of extracellular matrix in the myocardium leads to increased risk of arrhythmia …

Long-term elevated blood pressure will increase the cardiac load and lead to myocardial
fibrosis (MF). A variety of pathological mechanisms and signal transduction pathways are …