History and progress of hypotheses and clinical trials for Alzheimer's disease
PP Liu, Y Xie, XY Meng, JS Kang - Signal transduction and targeted …, 2019 - nature.com
Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive
memory loss along with neuropsychiatric symptoms and a decline in activities of daily life. Its …
memory loss along with neuropsychiatric symptoms and a decline in activities of daily life. Its …
Preclinical Alzheimer's disease: definition, natural history, and diagnostic criteria
During the past decade, a conceptual shift occurred in the field of Alzheimer's disease (AD)
considering the disease as a continuum. Thanks to evolving biomarker research and …
considering the disease as a continuum. Thanks to evolving biomarker research and …
Association of factors with elevated amyloid burden in clinically normal older individuals
RA Sperling, MC Donohue, R Raman, CK Sun… - JAMA …, 2020 - jamanetwork.com
Importance The Anti-Amyloid Treatment in Asymptomatic Alzheimer disease (A4) Study is an
ongoing prevention trial in clinically normal older individuals with evidence of elevated brain …
ongoing prevention trial in clinically normal older individuals with evidence of elevated brain …
Brain iron is associated with accelerated cognitive decline in people with Alzheimer pathology
S Ayton, Y Wang, I Diouf, JA Schneider… - Molecular …, 2020 - nature.com
Cortical iron has been shown to be elevated in Alzheimer's disease (AD), but the impact of
the directly measured iron on the clinical syndrome has not been assessed. We investigated …
the directly measured iron on the clinical syndrome has not been assessed. We investigated …
Practical recommendations for timely, accurate diagnosis of symptomatic Alzheimer's disease (MCI and dementia) in primary care: a review and synthesis
JL Liss, S Seleri Assunção, J Cummings… - Journal of internal …, 2021 - Wiley Online Library
The critical role of primary care clinicians (PCCs) in Alzheimer's disease (AD) prevention,
diagnosis and management must evolve as new treatment paradigms and disease …
diagnosis and management must evolve as new treatment paradigms and disease …
Associations of amyloid, tau, and neurodegeneration biomarker profiles with rates of memory decline among individuals without dementia
CR Jack, HJ Wiste, TM Therneau, SD Weigand… - Jama, 2019 - jamanetwork.com
Importance A National Institute on Aging and Alzheimer's Association workgroup proposed a
research framework for Alzheimer disease in which biomarker classification of research …
research framework for Alzheimer disease in which biomarker classification of research …
Sleep disturbance forecasts β-amyloid accumulation across subsequent years
Experimental sleep-wake disruption in rodents and humans causally modulates β-amyloid
(Aβ) dynamics (eg,[1–3]). This leads to the hypothesis that, beyond cross-sectional …
(Aβ) dynamics (eg,[1–3]). This leads to the hypothesis that, beyond cross-sectional …
An early and late peak in microglial activation in Alzheimer's disease trajectory
Amyloid-β deposition, neuroinflammation and tau tangle formation all play a significant role
in Alzheimer's disease. We hypothesized that there is microglial activation early on in …
in Alzheimer's disease. We hypothesized that there is microglial activation early on in …
The evolution of preclinical Alzheimer's disease: implications for prevention trials
As the field begins to test the concept of a" preclinical" stage of neurodegenerative disease,
when the pathophysiological process has begun in the brain, but clinical symptoms are not …
when the pathophysiological process has begun in the brain, but clinical symptoms are not …
Multimodal imaging in Alzheimer's disease: validity and usefulness for early detection
Alzheimer's disease is a progressive neurodegenerative disease that typically manifests
clinically as an isolated amnestic deficit that progresses to a characteristic dementia …
clinically as an isolated amnestic deficit that progresses to a characteristic dementia …