Allostery is largely associated with conformational and functional transitions in individual
proteins. This concept can be extended to consider the impact of conformational …

The architecture of interphase chromosomes is important for the regulation of gene
expression and genome maintenance. Chromosomes are linearly segmented into hundreds …

Despite an abundance of new studies about topologically associating domains (TADs), the
role of genetic information in TAD formation is still not fully understood. Here we use our …

Rapidly developing technologies have recently fueled an exciting era of discovery in the
field of chromosome structure and nuclear organization. In addition to chromosome …

Chromosome territories (CTs) constitute a major feature of nuclear architecture. In a brief
statement, the possible contribution of nuclear architecture studies to the field of …

Mammalian genomes are extensively transcribed, which produces a large number of both
coding and non-coding transcripts. Various RNAs are physically associated with chromatin …

Biological differences among metazoans and between cell types in a given organism arise
in large part due to differences in gene expression patterns. Gene-distal enhancers are key …

Nuclear bodies including nucleoli, Cajal bodies, nuclear speckles, Polycomb bodies, and
paraspeckles are membraneless subnuclear organelles. They are present at steady-state …

Mammalian genomes are pervasively transcribed outside mapped protein-coding genes.
One class of extragenic transcription products is represented by long non-coding RNAs …

Transcription is reported to be spatially compartmentalized in nuclear transcription factories
with clusters of RNA polymerase II (Pol II). However, little is known about when these foci …