In the ageing skeleton, the balance of bone reconstruction could commonly be broken by the
increasing of bone resorption and decreasing of bone formation. Consequently, the bone …

Melatonin's therapeutic potential has been highly underestimated because its biological
functional roles are diverse and relevant mechanisms are complicated. Among the …

Background/Aims: Osteoporosis is a metabolic bone disorder that tortures about millions of
people worldwide. Recent study demonstrated agents derived from picrasma quassioides is …

Picrorhiza kurroa, the dried rhizome of Picrorhiza kurroa Royle ex Benth, is a famous
Chinese herb that has been traditionally used in China. Picroside II (PII), a glycoside …

Although studies have established the role of integrins in bone homeostasis, especially in
osteoclastogenesis, and these molecules are novel and promising therapeutic drug targets …

The nuclear factor kappa B (NF-ΚB) consists of a family of transcription factors involved in
the regulation of a wide variety of biological responses. Growing evidence support that NF …

Osteoclasts are sole bone-resorbing cells which exert a profound effect on skeletal
metabolism. The search for medicines that affect the differentiation and function of …

Myricitrin is a natural occurring flavonoid glycoside that possesses effects on inhibiting nitric
oxide (NO) transmission and preventing inflammatory reaction. Although previous study …

Bone homeostasis requires a dynamic balance between osteogenesis and
osteoclastogenesis, and osteolytic disorders are mainly attributed to aberrant …

Osteoporosis has traditionally been characterized by underlying endocrine mechanisms,
though evidence indicates a role of inflammation in its pathophysiology. Lipopolysaccharide …