Osteoporosis, a condition of skeletal decline that undermines quality of life, is treated with
pharmacological interventions that are associated with poor adherence and adverse effects …

Aging represents the single greatest risk factor for chronic diseases, including osteoporosis,
a skeletal fragility syndrome that increases fracture risk. Optimizing bone strength throughout …

Closed circulatory systems underlie the function of vertebrate organs, but in long bones their
structure is unclear although they constitute the exit route for bone marrow (BM) leukocytes …

Clinical radiotherapy treats life‐threatening cancers, but the radiation often affects
neighboring normal tissues including bone. Acute effects of ionizing radiation include …

Chemotherapy is important for cancer treatment, however, toxicities limit its use. While great
strides have been made to ameliorate the acute toxicities induced by chemotherapy, long …

Mesenchymal stromal cells (MSCs) can differentiate to various cell types including
osteoblasts, chondrocytes, and adipocytes. This cellular flexibility contributes to widespread …

The bone is a complex organ that is dependent on a tight regulation between bone
formation by osteoblasts (OBs) and bone resorption by osteoclasts (OCs). These processes …

Focal radiotherapy is frequently associated with skeletal damage within the radiation field.
Our previous in vitro study showed that activation of Wnt/β‐catenin pathway can overcome …

Radiotherapy increases tumor cure and survival rates; however, radiotherapy-induced bone
damage remains a common issue for which effective countermeasures are lacking …

Radiotherapy is a commonly used conditioning regimen for bone marrow transplantation
(BMT). Cytotoxicity limits the use of this life-saving therapy, but the underlying mechanisms …