The role of CREB and BDNF in neurobiology and treatment of Alzheimer's disease
Alzheimer's disease (AD) is the most common form of dementia worldwide. β-amyloid
peptide (Aβ) is currently assumed to be the main cause of synaptic dysfunction and cognitive …
peptide (Aβ) is currently assumed to be the main cause of synaptic dysfunction and cognitive …
Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs
Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …
Chemical Biology of H2S Signaling through Persulfidation
MR Filipovic, J Zivanovic, B Alvarez… - Chemical …, 2018 - ACS Publications
Signaling by H2S is proposed to occur via persulfidation, a posttranslational modification of
cysteine residues (RSH) to persulfides (RSSH). Persulfidation provides a framework for …
cysteine residues (RSH) to persulfides (RSSH). Persulfidation provides a framework for …
Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter
JL Wallace, R Wang - Nature reviews Drug discovery, 2015 - nature.com
Hydrogen sulfide (H2S) has become recognized as an important signalling molecule
throughout the body, contributing to many physiological and pathological processes. In …
throughout the body, contributing to many physiological and pathological processes. In …
Progress and perspective on hydrogen sulfide donors and their biomedical applications
ZL Song, L Zhao, T Ma, A Osama… - Medicinal Research …, 2022 - Wiley Online Library
Following the discovery of nitric oxide (NO) and carbon monoxide (CO), hydrogen sulfide
(H2S) has been identified as the third gasotransmitter in humans. Increasing evidence have …
(H2S) has been identified as the third gasotransmitter in humans. Increasing evidence have …
Mechanisms of action involved in ozone therapy: is healing induced via a mild oxidative stress?
M Sagai, V Bocci - Medical gas research, 2011 - Springer
The potential mechanisms of action of ozone therapy are reviewed in this paper. The
therapeutic efficacy of ozone therapy may be partly due the controlled and moderate …
therapeutic efficacy of ozone therapy may be partly due the controlled and moderate …
Hydrogen sulfide and cellular redox homeostasis
Intracellular redox imbalance is mainly caused by overproduction of reactive oxygen species
(ROS) or weakness of the natural antioxidant defense system. It is involved in the …
(ROS) or weakness of the natural antioxidant defense system. It is involved in the …
The impact of trace minerals on bone metabolism
E Gaffney-Stomberg - Biological trace element research, 2019 - Springer
Bone is a metabolically active tissue that responds to alterations in dietary intake and
nutritional status. It is~ 35% protein, mostly collagen which provides an organic scaffolding …
nutritional status. It is~ 35% protein, mostly collagen which provides an organic scaffolding …
Persulfidation (S-sulfhydration) and H2S
MR Filipovic - … , biochemistry and pharmacology of hydrogen sulfide, 2015 - Springer
The past decade has witnessed the discovery of hydrogen sulfide (H 2 S) as a new
signalling molecule. Its ability to act as a neurotransmitter, regulator of blood pressure …
signalling molecule. Its ability to act as a neurotransmitter, regulator of blood pressure …
Hydrogen sulfide: an endogenous mediator of resolution of inflammation and injury
JL Wallace, JGP Ferraz, MN Muscara - Antioxidants & redox …, 2012 - liebertpub.com
Significance: Hydrogen sulfide is emerging as an important mediator of many aspects of
inflammation, and perhaps most importantly as a factor promoting the resolution of …
inflammation, and perhaps most importantly as a factor promoting the resolution of …