The role of CREB and BDNF in neurobiology and treatment of Alzheimer's disease

M Amidfar, J de Oliveira, E Kucharska, J Budni, YK Kim - Life sciences, 2020 - Elsevier
Alzheimer's disease (AD) is the most common form of dementia worldwide. β-amyloid
peptide (Aβ) is currently assumed to be the main cause of synaptic dysfunction and cognitive …

Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs

G Cirino, C Szabo… - Physiological …, 2023 - journals.physiology.org
Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …

Chemical Biology of H2S Signaling through Persulfidation

MR Filipovic, J Zivanovic, B Alvarez… - Chemical …, 2018 - ACS Publications
Signaling by H2S is proposed to occur via persulfidation, a posttranslational modification of
cysteine residues (RSH) to persulfides (RSSH). Persulfidation provides a framework for …

Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter

JL Wallace, R Wang - Nature reviews Drug discovery, 2015 - nature.com
Hydrogen sulfide (H2S) has become recognized as an important signalling molecule
throughout the body, contributing to many physiological and pathological processes. In …

Progress and perspective on hydrogen sulfide donors and their biomedical applications

ZL Song, L Zhao, T Ma, A Osama… - Medicinal Research …, 2022 - Wiley Online Library
Following the discovery of nitric oxide (NO) and carbon monoxide (CO), hydrogen sulfide
(H2S) has been identified as the third gasotransmitter in humans. Increasing evidence have …

Mechanisms of action involved in ozone therapy: is healing induced via a mild oxidative stress?

M Sagai, V Bocci - Medical gas research, 2011 - Springer
The potential mechanisms of action of ozone therapy are reviewed in this paper. The
therapeutic efficacy of ozone therapy may be partly due the controlled and moderate …

Hydrogen sulfide and cellular redox homeostasis

ZZ Xie, Y Liu, JS Bian - Oxidative medicine and cellular …, 2016 - Wiley Online Library
Intracellular redox imbalance is mainly caused by overproduction of reactive oxygen species
(ROS) or weakness of the natural antioxidant defense system. It is involved in the …

The impact of trace minerals on bone metabolism

E Gaffney-Stomberg - Biological trace element research, 2019 - Springer
Bone is a metabolically active tissue that responds to alterations in dietary intake and
nutritional status. It is~ 35% protein, mostly collagen which provides an organic scaffolding …

Persulfidation (S-sulfhydration) and H2S

MR Filipovic - … , biochemistry and pharmacology of hydrogen sulfide, 2015 - Springer
The past decade has witnessed the discovery of hydrogen sulfide (H 2 S) as a new
signalling molecule. Its ability to act as a neurotransmitter, regulator of blood pressure …

Hydrogen sulfide: an endogenous mediator of resolution of inflammation and injury

JL Wallace, JGP Ferraz, MN Muscara - Antioxidants & redox …, 2012 - liebertpub.com
Significance: Hydrogen sulfide is emerging as an important mediator of many aspects of
inflammation, and perhaps most importantly as a factor promoting the resolution of …