Glutamate is the most commonly engaged neurotransmitter in the mammalian central
nervous system, acting to mediate excitatory neurotransmission. However, high levels of …

New discoveries providing insights into mitochondrial bioenergetics, their dynamic
interactions as well as their role in cellular homeostasis have dramatically advanced our …

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterised by the
preferential loss of dopaminergic neurons in the substantia nigra. Mitochondrial dysfunction …

Mitochondrial plasticity is a key regulator of cell fate decisions. Mitochondrial division
involves Dynamin-related protein-1 (Drp1) oligomerization, which constricts membranes at …

Increased production of reactive oxygen species (ROS) has long been considered a cause
of aging. However, recent studies have implicated ROS as essential secondary messengers …

Over the past 20 years, the concept of mammalian autophagy as a nonselective degradation
system has been repudiated, due in part to important discoveries in neurodegenerative …

Mitochondrial quality control is central for maintaining a healthy population of mitochondria.
Two Parkinson's disease genes, mitochondrial kinase PINK1 and ubiquitin ligase Parkin …

Mitochondria are organelles with vital functions in almost all eukaryotic cells. Often
described as the cellular 'powerhouses' due to their essential role in aerobic oxidative …

Maintaining mitochondrial health is essential for the survival and function of eukaryotic
organisms. Misfunctioning mitochondria activate stress-responsive pathways to restore …

The early pathogenesis and underlying molecular causes of motor neuron degeneration in
Parkinson's Disease (PD) remains unresolved. In the model organism Drosophila …