Background Every year, at least one million children become ill with tuberculosis and
around 200,000 children die. Xpert MTB/RIF and Xpert Ultra are World Health Organization …

Invasive collection methods are often required to obtain samples for the microbiological
evaluation of children with presumptive pulmonary tuberculosis (PTB). Nucleic acid …

The objectives of the 2022 consolidated guidelines are: to provide policy makers and
implementing partners with evidence-based recommendations on the cascade of care for …

Background The World Health Organization (WHO) and Foundation for Innovative New
Diagnostics (FIND) have published target product profiles (TPPs) calling for non-sputum …

Children bear a substantial burden of suffering when it comes to tuberculosis. Ironically, they
are often left out of the scientific and public health advances that have led to important …

Importance Criterion-standard specimens for tuberculosis diagnosis in young children,
gastric aspirate (GA) and induced sputum, are invasive and rarely collected in resource …

There is no microbiological gold standard for childhood tuberculosis (TB) diagnosis. The
paucibacillary nature of the disease, challenges in sample collection in young children, and …

Background: Tuberculosis (TB) causes substantial morbidity and mortality in HIV-infected
children. Sample collection and the paucibacillary nature of TB in children makes diagnosis …

Background Limitations in the sensitivity and accessibility of diagnostic tools for childhood
tuberculosis contribute to the substantial gap between estimated cases and cases notified to …

Objectives The WHO currently recommends stool testing using GeneXpert MTB/Rif (Xpert)
for the diagnosis of paediatric tuberculosis (TB). The simple one-step (SOS) stool method …